ZICHEN LIU1,#, SIYAO GUO2,3,#, MENGZHI JI1, KAILI SUN1, ZHONGFANG LI4,*, XIANGYU FAN1,*
BIOCELL, Vol.44, No.4, pp. 683-694, 2020, DOI:10.32604/biocell.2020.011713
- 24 December 2020
Abstract Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide, particularly in developing
countries. A rapid and efficient method for TB diagnosis is indispensable to check the trend of tuberculosis
expansion. The emergence of drug-resistant bacteria has increased the challenge of rapid drug resistance tests. Due to
its high specificity and sensitivity, bacteriophage-based diagnosis is intensively pursued. In this review, we mainly
described mycobacteriophage-based diagnosis in TB detection, especially two prevalent approaches: fluorescent
reporter phage and phage amplified biologically assay (PhaB). The rationale of reporter phage is that phage carrying
fluorescent genes can infect More >
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