SHAIL RAKESH MODI, TERRICK ANDEY^*

Oncology Research, Vol.32, No.11, pp. 1709-1721, 2024, DOI:10.32604/or.2024.053972 - 16 October 2024

Abstract Objectives: EGFR tyrosine kinase inhibitor (EGFR-TKI) therapies such as erlotinib and gefitinib are approved for the treatment of non-small cell lung cancer (NSCLC). However, the high incidence of acquired resistance to these EGFR-TKIs may preclude their effectiveness. Piperlongumine (PPL), an extract from the long pepper fruit (Piper longum), has been shown to possess anticancer properties. The purpose of the study was to investigate piperlongumine as an anticancer agent and to study a combination treatment approach with EGFR-TKIs against lung cancer cells. Methods: Anticancer efficacy of PPL, erlotinib (ERL), gefitinib (GEF), and cisplatin (CIS) were investigated in… More >

YOUSEF KATIB^1,*, NASSER MULLA²

Oncology Research, Vol.32, No.11, pp. 1803-1809, 2024, DOI:10.32604/or.2024.052358 - 16 October 2024

Abstract Background: Lung cancer (LC) is one of the most common neoplastic diseases and a leading cause of death in Saudi Arabia. Its incidence in Saudi Arabia has increased by more than 3% within two decades. Our study aimed to describe the epidemiological and genetic landscapes of LC in Al-Madinah city in Saudi Arabia. Methods: A retrospective analysis was conducted on the medical records of 65 patients diagnosed with lung cancer between 2015 and 2021 at a single medical oncology center in Al-Madinah city of Saudi Arabia. Results: The mean patients’ age was 59.2 years, with 50… More >

Liang Zeng^1,2,3, Ziyang Ding¹, Junyang Shi¹, Shanshan Wang^1,2,3,*

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1757-1787, 2024, DOI:10.32604/cmc.2024.055574 - 15 October 2024

Abstract In the manufacturing industry, reasonable scheduling can greatly improve production efficiency, while excessive resource consumption highlights the growing significance of energy conservation in production. This paper studies the problem of energy-efficient distributed heterogeneous permutation flowshop problem with variable processing speed (DHPFSP-VPS), considering both the minimum makespan and total energy consumption (TEC) as objectives. A discrete multi-objective squirrel search algorithm (DMSSA) is proposed to solve the DHPFSP-VPS. DMSSA makes four improvements based on the squirrel search algorithm. Firstly, in terms of the population initialization strategy, four hybrid initialization methods targeting different objectives are proposed to enhance… More >

Zakir Hussain Ahmed^1,*, Maha Ata Al-Furhood², Abdul Khader Jilani Saudagar³, Shakir Khan⁴

Computer Systems Science and Engineering, Vol.48, No.5, pp. 1113-1131, 2024, DOI:10.32604/csse.2024.053574 - 13 September 2024

Abstract The generalized travelling salesman problem (GTSP), a generalization of the well-known travelling salesman problem (TSP), is considered for our study. Since the GTSP is NP-hard and very complex, finding exact solutions is highly expensive, we will develop genetic algorithms (GAs) to obtain heuristic solutions to the problem. In GAs, as the crossover is a very important process, the crossover methods proposed for the traditional TSP could be adapted for the GTSP. The sequential constructive crossover (SCX) and three other operators are adapted to use in GAs to solve the GTSP. The effectiveness of GA using More >

YUZHI LIU^1,#, EVELYNE BISCHOF^2,#, ZHIQIN CHEN¹, JIAHUAN ZHOU³, BEI ZHANG⁴, DING ZHANG⁴, YONG GAO^1,*, MING QUAN^1,*

Oncology Research, Vol.32, No.9, pp. 1429-1438, 2024, DOI:10.32604/or.2024.047309 - 23 August 2024

Abstract Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes, tumor mutational burden, microsatellite instability, and programmed death ligand 1 (PD-L1) expression. Results: Among 2454 CRC patients, 85 cases (3.46%) exhibited ERBB2 amplification, and 55 cases (2.24%) carried ERBB2 mutation.… More > Graphic Abstract

Shujing Li, Zhangfei Li, Wenhui Cheng, Chenyang Qi, Linguo Li^*

CMC-Computers, Materials & Continua, Vol.80, No.2, pp. 2049-2063, 2024, DOI:10.32604/cmc.2024.051928 - 15 August 2024

Abstract To enhance the diversity and distribution uniformity of initial population, as well as to avoid local extrema in the Chimp Optimization Algorithm (CHOA), this paper improves the CHOA based on chaos initialization and Cauchy mutation. First, Sin chaos is introduced to improve the random population initialization scheme of the CHOA, which not only guarantees the diversity of the population, but also enhances the distribution uniformity of the initial population. Next, Cauchy mutation is added to optimize the global search ability of the CHOA in the process of position (threshold) updating to avoid the CHOA falling More >

Jiahui Liu^1,2, Lang Li^1,2,*, Di Li^1,2, Yu Ou^1,2

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4641-4657, 2024, DOI:10.32604/cmc.2024.051613 - 20 June 2024

Abstract Correlation power analysis (CPA) combined with genetic algorithms (GA) now achieves greater attack efficiency and can recover all subkeys simultaneously. However, two issues in GA-based CPA still need to be addressed: key degeneration and slow evolution within populations. These challenges significantly hinder key recovery efforts. This paper proposes a screening correlation power analysis framework combined with a genetic algorithm, named SFGA-CPA, to address these issues. SFGA-CPA introduces three operations designed to exploit CPA characteristics: propagative operation, constrained crossover, and constrained mutation. Firstly, the propagative operation accelerates population evolution by maximizing the number of correct bytes… More >

Lili Bai^1,*, Wenhui Li¹, He Ren^1,2, Feng Li¹, Tao Yan¹, Lirong Chen³

CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 4513-4531, 2024, DOI:10.32604/cmc.2024.051348 - 20 June 2024

Abstract Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery, where weak fault characteristic signals hinder accurate fault state representation, we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform (FAWT) with Nonlinear Quantum Permutation Entropy. FAWT, leveraging fractional orders and arbitrary scaling and translation factors, exhibits superior translational invariance and adjustable fundamental oscillatory characteristics. This flexibility enables FAWT to provide well-suited wavelet shapes, effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults. In our approach,… More >

Sichen Li^1,2, Dehua Liu^1,2,*, Liang Cheng^1,2, Pan Ma^1,2

Energy Engineering, Vol.121, No.7, pp. 1921-1943, 2024, DOI:10.32604/ee.2024.049906 - 11 June 2024

Abstract Due to the depletion of conventional energy reserves, there has been a global shift towards non-conventional energy sources. Shale oil and gas have emerged as key alternatives. These resources have dense and heterogeneous reservoirs, which require hydraulic fracturing to extract. This process depends on identifying optimal fracturing layers, also known as ‘sweet spots’. However, there is currently no uniform standard for locating these sweet spots. This paper presents a new model for evaluating fracturability that aims to address the current gap in the field. The model utilizes a hierarchical analysis approach and a mutation model, More > Graphic Abstract

MAHER KURDI^1,*, ALAA ALKHOTANI², ABDULRAHMAN SABBAGH³, EYAD FAIZO⁴, AHMED I. LARY⁵, AHMED K. BAMAGA⁶, MAJID ALMANSOURI⁷, BADR HAFIZ⁸, THAMER ALSHARIF⁹, SALEH BAEESA⁸

Oncology Research, Vol.32, No.6, pp. 1037-1045, 2024, DOI:10.32604/or.2024.051112 - 23 May 2024

Abstract Background: The dysregulation of Isocitrate dehydrogenase (IDH) and the subsequent production of 2-Hydroxyglutrate (2HG) may alter the expression of epigenetic proteins in Grade 4 astrocytoma. The interplay mechanism between IDH, O-6-methylguanine-DNA methyltransferase (MGMT)-promoter methylation, and protein methyltransferase proteins-5 (PRMT5) activity, with tumor progression has never been described. Methods: A retrospective cohort of 34 patients with G4 astrocytoma is classified into IDH-mutant and IDH-wildtype tumors. Both groups were tested for MGMT-promoter methylation and PRMT5 through methylation-specific and gene expression PCR analysis. Inter-cohort statistical significance was evaluated. Results: Both IDH-mutant WHO grade 4 astrocytomas (n = 22, 64.7%) and IDH-wildtype… More > Graphic Abstract