ALEKSANDRA GORNOSTAEVA, ELENA ANDREEVA*, LUDMILA BURAVKOVA*
BIOCELL, Vol.46, No.9, pp. 2049-2052, 2022, DOI:10.32604/biocell.2022.019993
- 18 May 2022
Abstract Multipotent mesenchymal stromal cells (MSCs) are actively involved in reparation and inflammation processes,
providing damaged tissue reparation and suppressing immune cell responses in vivo. The effects are mostly due to the
production of a wide range of paracrine factors, including growth factors and immunomodulatory mediators. To induce
immunosuppressive activity, MSCs are primed by inflammatory cytokines, which results in an increased production of
immunomodulatory molecules. However, stimulation of reparative properties is also necessary. This viewpoint
manuscript highlights the possibilities of inflammatory priming to increase the production of growth factors by MSCs. More >
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