Majed Al Fayi*†, Ahmad Alamri*, Prasanna Rajagopalan*†
Oncology Research, Vol.28, No.2, pp. 177-189, 2020, DOI:10.3727/096504019X15746768080428
Abstract Drug discovery research to fight lung cancer is incessantly challenged by drug resistance. In this study, we
used drug-resistant lung cancer stem like cells (A549-CS) to compare the efficacy of standard drugs like cisplatin (DDP) and gemcitabine (GEM) with a novel arylidene derivative IOX-101. A549-CS was derived from
regular A549 cells by growing in special media. Resistance proteins were detected using Western blotting. Cell
proliferations were assessed by MTT assay. Cytokine release was enumerated using enzyme-linked immunosorbent assay. The effect of drugs on apoptosis and cell cycle was studied with flow cytometry protocols.
Apoptosis-related proteins,… More >
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