FANBIAO KONG1,2,#, KUN WU3,4,#, LIMING PANG2,#, YULIANG HUANG2,#, LEI LI3, JING XU2, FEITONG LI2, YAN QING2, ZHONGYU WANG2, XIURONG HUANG3, SHENG XU2, XIAOGANG ZHONG2, ZHOU ZHU2, XIAOTONG WANG3,*, JIANRONG YANG5,*
Oncology Research, Vol.30, No.6, pp. 277-288, 2022, DOI:10.32604/or.2022.027301
- 09 February 2023
Abstract Introduction: Siva-1, as a pro-apoptotic protein, has been shown to induce extensive apoptosis in a number of
different cell lines. In our previous study, we showed that overexpressed Siva-1 decreased the apoptosis of gastric cancer
cells. So, we believe that it can also work as an anti-apoptotic protein. The present study aimed to determine the specific
role of Siva-1 in anticancer drug resistance in gastric cancer in vivo and in vitro and preliminarily reveal the mechanism.
Materials and Methods: A vincristine-resistant MKN-28/VCR gastric cancer cell line with stably downregulated Siva-1
was established. The effect of Siva-1 downregulation… More >
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