XIAOYU WANG1,2,#,*, TAKESHI YAMAMOTO2,#, MAKOTO KADOWAKI2, YIFU YANG1
BIOCELL, Vol.45, No.2, pp. 395-415, 2021, DOI:10.32604/biocell.2021.012280
Abstract Mast cells are the main effector cells in IgE-associated allergic disorders, and we have reported that mucosal
mast cells (MMCs) play a more important role in the development of food allergy (FA). IgE with antigen or calcium
ionophore stimulation can lead to the activation of MMCs via a calcium-dependent pathway. The purpose of the
present study was to identify gene signatures with IgE/antigen (dinitrophenyl-bovine serum albumin, DNP-BSA) or
calcium ionophore (A23187) on the activation of MMCs. Differentially expressed genes between the two types of
samples were identified with microarray analysis. Gene ontology functional and pathway… More >
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