RAQUEL GÓMEZ-MOLINA^1,*, RAQUEL MARTÍNEZ^2,3,4, MIGUEL SUÁREZ^2,3,4,*, ANA PEÑA-CABIA¹, MARíA CONCEPCIóN CALDERÓN¹, JORGE MATEO^3,4

Oncology Research, Vol.33, No.7, pp. 1531-1545, 2025, DOI:10.32604/or.2025.063951 - 26 June 2025

Abstract Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer (HNPCC), is an inherited condition associated with a higher risk of colorectal cancer (CRC) and other cancers. It is caused by germline mutations in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6 and PMS2. These mutations lead to microsatellite instability (MSI) and defective DNA repair mechanisms, resulting in increased cancer risk. Early detection of LS is crucial for effective management and cancer prevention. Endoscopic surveillance, particularly regular colonoscopy, is recommended for individuals with LS to detect CRC at early stages. Additionally, universal screening of CRC for More > Graphic Abstract

TINGTING LIU^1,#, YIWEI HAO^2,#, LIFENG ZHAO^2,*

BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130 - 06 May 2024

Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry… More >

M. Ashraf Ahangar¹, Shabir Hussain Wani^1,*, Zahoor A. Dar², Jan Roohi¹, Fayaz Mohiddin¹, Monika Bansal³, Mukesh Choudhary⁴, Sumit K. Aggarwal⁴, S. A. Waza¹, Khursheed Ahmad Dar⁵, Ayman El Sabagh^6,7, Celaleddin Barutcular⁸, Omer Konuşkan⁹, Mohammad Anwar Hossain^10,*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2111-2133, 2022, DOI:10.32604/phyton.2022.020721 - 30 May 2022

Abstract Maize is cultivated extensively throughout the world and has the highest production among cereals. However, Northern corn leaf blight (NCLB) disease caused by Exherohilum turcicum, is the most devastating limiting factor of maize production. The disease causes immense losses to corn yield if it develops prior or during the tasseling and silking stages of crop development. It has a worldwide distribution and its development is favoured by cool to moderate temperatures with high relative humidity. The prevalence of the disease has increased in recent years and new races of the pathogen have been reported worldwide. The… More >