Yidong Cao^*1, Liang Zhang^*1, Minghao Wei^*, Xue Jiang^†, Dong Jia^*

Oncology Research, Vol.25, No.7, pp. 1097-1107, 2017, DOI:10.3727/096504017X14836170586829

Abstract Emerging evidence has suggested that aberrantly expressed microRNAs (miRNAs) are associated with glioma development and progression. The aberrant expression of miR-409-3p has been reported in several human cancers. However, little is known about the function of miR-409-3p in gliomas. The aim of this study was to investigate the specific role and molecular mechanism of miR-409-3p in gliomas. In the present study, we found that miR-409-3p was downregulated in glioma tissue and cell lines. Overexpression of miR-409-3p inhibited glioma cell invasion and proliferation, whereas suppression of miR-409-3p promoted glioma cell invasion and proliferation. High-mobility group nucleosome-binding More >

Zhiqiang Liu^*1, Qiang Li^*1, Xin Zhao^†, Bin Cui^*, Libo Zhang^*, Qiang Wang^*

Oncology Research, Vol.26, No.9, pp. 1439-1446, 2018, DOI:https://doi.org/10.3727/096504018X15189093975640

Abstract Numerous studies have suggested that microRNAs (miRNAs) are dysregulated in osteosarcoma (OS), implicating miRNAs in OS initiation and progression. Therefore, knowledge of aberrantly expressed miRNAs in OS may provide novel mechanistic insights into the tumorigenesis and tumor development of OS and facilitate therapeutic methods for patients with this aggressive bone neoplasm. In this study, data obtained from reverse transcription quantitative polymerase chain reaction (RT-qPCR) revealed that miR-935 was significantly decreased in OS tissues and cell lines. Restoration expression of miR-935 obviously restricted proliferation and invasion of OS cells. In addition, high-mobility group box 1 (HMGB1)… More >

Pengwei Lu, Yuanting Gu, Lin Li, Fang Wang, Xue Yang, Yunqing Yang

Oncology Research, Vol.26, No.4, pp. 625-635, 2018, DOI:10.3727/096504017X14953948675395

Abstract Breast cancer is a serious threat to women’s physical and psychological health. Long noncoding RNA CAMTA1 (lncCAMTA1) was believed to be related with tumor progression, but its role in breast cancer is not clear. The human breast cancer cell line MDA-MB-231 was used to investigate the effect of lncCAMTA1 on cell viability, migration/invasion, and apoptosis. The expression of lncCAMTA1, miR-20b, and VEGF in MDAMB-231 were measured after corresponding transfections. Binding effects between lncCAMTA1 and miR-20b, miR-20b, and VEGF 3'-UTR were measured. The effects of miR-20b and VEGF on breast cancer cells were also assessed after… More >

Dandan Li^*, Changjun He^†, Junfeng Wang^†, Yanbo Wang^†, Jianlong Bu^†, Xianglong Kong^†, Dawei Sun^†

Oncology Research, Vol.26, No.3, pp. 385-400, 2018, DOI:10.3727/096504017X14973124850905

Abstract Many studies have shown that downregulation of miR-138 occurs in a variety of cancers including non-small cell lung cancer (NSCLC). However, the precise mechanisms of miR-138 in NSCLC have not been well clarified. In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could turn out to be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is downregulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in… More >

Yu Zhou¹, Bosong Lin¹, Siqi Hu², Dandan Yu^3,*

CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 161-182, 2024, DOI:10.32604/cmc.2024.047836

Abstract This paper addresses the problem of predicting population density leveraging cellular station data. As wireless communication devices are commonly used, cellular station data has become integral for estimating population figures and studying their movement, thereby implying significant contributions to urban planning. However, existing research grapples with issues pertinent to preprocessing base station data and the modeling of population prediction. To address this, we propose methodologies for preprocessing cellular station data to eliminate any irregular or redundant data. The preprocessing reveals a distinct cyclical characteristic and high-frequency variation in population shift. Further, we devise a multi-view More >

Yong Ma¹, Han Zhao², Kunyin Guo^3,*, Yunni Xia^3,*, Xu Wang⁴, Xianhua Niu⁵, Dongge Zhu⁶, Yumin Dong⁷

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 907-927, 2024, DOI:10.32604/cmes.2024.048759

Abstract Mobile Edge Computing (MEC) is a technology designed for the on-demand provisioning of computing and storage services, strategically positioned close to users. In the MEC environment, frequently accessed content can be deployed and cached on edge servers to optimize the efficiency of content delivery, ultimately enhancing the quality of the user experience. However, due to the typical placement of edge devices and nodes at the network’s periphery, these components may face various potential fault tolerance challenges, including network instability, device failures, and resource constraints. Considering the dynamic nature of MEC, making high-quality content caching decisions… More >

Amal Hkiri^1,*, Mouna Karmani¹, Omar Ben Bahri², Ahmed Mohammed Murayr², Fawaz Hassan Alasmari², Mohsen Machhout¹

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 227-247, 2024, DOI:10.32604/cmc.2023.047087

Abstract The RPL (IPv6 Routing Protocol for Low-Power and Lossy Networks) protocol is essential for efficient communication within the Internet of Things (IoT) ecosystem. Despite its significance, RPL’s susceptibility to attacks remains a concern. This paper presents a comprehensive simulation-based analysis of the RPL protocol’s vulnerability to the decreased rank attack in both static and mobile network environments. We employ the Random Direction Mobility Model (RDM) for mobile scenarios within the Cooja simulator. Our systematic evaluation focuses on critical performance metrics, including Packet Delivery Ratio (PDR), Average End to End Delay (AE2ED), throughput, Expected Transmission Count More >

Hailong Nie¹, Xincheng Shi¹, Wenkui Yang¹, Kaile Wang¹, Yuhong Zhao^2,1,3,*

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1425-1443, 2023, DOI:10.32604/cmc.2023.044510

Abstract Previous studies of hydride in zirconium alloys have mainly assumed an isotropic interface. In practice, the difference in crystal structure at the interface between the matrix phase and the precipitate phase results in an anisotropic interface. With the purpose of probing the real evolution of hydrides, this paper couples an anisotropy function in the interfacial energy and interfacial mobility. The influence of anisotropic interfacial energy and interfacial mobility on the morphology of hydride precipitation was investigated using the phase-field method. The results show that the isotropy hydride precipitates a slate-like morphology, and the anisotropic hydride… More >

Y. M. Mahaboob John^1,*, G. Ravi²

Computer Systems Science and Engineering, Vol.46, No.3, pp. 3653-3666, 2023, DOI:10.32604/csse.2023.036916

Abstract Mobile Ad-hoc Network (MANET) routing problems are thoroughly studied several approaches are identified in support of MANET. Improve the Quality of Service (QoS) performance of MANET is achieving higher performance. To reduce this drawback, this paper proposes a new secure routing algorithm based on real-time partial ME (Mobility, energy) approximation. The routing method RRME (Real-time Regional Mobility Energy) divides the whole network into several parts, and each node’s various characteristics like mobility and energy are randomly selected neighbors accordingly. It is done in the path discovery phase, estimated to identify and remove malicious nodes. In… More >

Jing Zhao, Jun Yang^*

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.7, pp. 1951-1961, 2023, DOI:10.32604/fdmp.2023.026115

Abstract Low-Tension-Foam (LTF) flooding is an emerging enhanced oil recovery technique for low-permeability carbonate reservoirs. Foam capacity is closely related to the salinity environment (or, equivalently, the phase behavior of the oil/water/surfactant system). Therefore, the interactions between microemulsion and foam components are of primary importance in the LTF process. In this study, the phase behavior of an oil/water/surfactant system under equilibrium is analyzed, firstly by assuming perfect mixing. Meanwhile, the formation kinetics of microemulsion are monitored through a novel low-field NMR technique, which is able to provide quantitative assessment on the microemulsion evolution characteristics. Then, foam More >