Bo Hu*, Xunbo Jin*, Jianbo Wang†
Oncology Research, Vol.26, No.7, pp. 1093-1102, 2018, DOI:10.3727/096504018X15154112497142
Abstract Prostate cancer (PCa) is the second most commonly diagnosed malignancy and the fifth leading cause of
cancer-related deaths in males worldwide. MicroRNAs (miRNAs) may serve as important regulators in PCa
occurrence and development. Therefore, understanding the expression and functions of PCa-related miRNAs
may be beneficial for the identification of novel therapeutic methods for patients with PCa. In this study,
miRNA-212 (miR-212) was evidently downregulated in PCa tissues and several PCa cell lines. Functional
assays showed that the resumption of miR-212 expression attenuated cell proliferation and invasion and
increased the apoptosis of PCa. In addition, mitogen-activated More >
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