TINGTING LIU^#, DINGYOU GUO^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.8, pp. 1155-1179, 2024, DOI:10.32604/biocell.2024.051518

Abstract In China, Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative illness affecting middle-aged and older persons. Movement disorders including resting tremor, bradykinesia, myotonia, postural instability, and gait instability are the predominant clinical symptoms. The two main types of PD are sporadic and familial, with sporadic PD being the more prevalent of the two. The environment, genetics, mitochondrial dysfunction, oxidative stress, inflammation, protein aggregation and misfolding, loss of trophic factors, cell death, and gut microbiota may all have a role in the etiology of PD. PD is inversely connected with other More >

S.S. Bombicino^*, D.E. Iglesias, I.A. Rukavina Mikusic, A. Boveris, L.B. Valdez

BIOCELL, Vol.40, No.1, pp. 7-10, 2016, DOI:10.32604/biocell.2016.40.007

Abstract Diabetic cardiomyopathy, i.e. the ventricular dysfunction in the absence of hypertension or coronary arterial disease, is a common complication of diabetes mellitus that leads to a heightened risk of heart failure and death among diabetic patients. This contractile dysfunction could be associated to mitochondrial dysfunction, in which mitochondrial biogenesis could emerge as a compensatory mechanism triggered in response to hyperglycemia. It has been proposed that nitric oxide synthase activities with enhanced NO production are involved in this process. Alterations in the contractile response and lusitropic reserve were observed in streptozotocin diabetic rats after β-adrenergic stimuli. Additionally,… More >