KAITIAN ZHANG^1,#, MINGZHU LI^2,#,*, JIANPING ZHANG³, JINFENG LI², KUNLANG LI², HUANQIAN LU², JINYAN LV²

BIOCELL, Vol.48, No.10, pp. 1489-1501, 2024, DOI:10.32604/biocell.2024.053930 - 02 October 2024

Abstract Objective: Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion (MI/R) can confer cardioprotective benefits. This study investigates whether Lovastatin can modulate the Yes-associated protein/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ) signaling pathway to mitigate cardiomyocyte injury caused by hypoxia/reoxygenation (H/R). Methods: The in vitro MI/R model was established by H/R in rat myocardial H9c2 cells, and the cells were pretreated with varying doses of Lovastatin before reoxygenation. The extent of cellular injury was evaluated by measuring the myocardial enzyme content and cell viability. The levels of oxidative stress and inflammatory factors were quantified by enzyme-linked… More > Graphic Abstract

VINíCIUS AUGUSTO SIMãO¹, LUIZ GUSTAVO DE ALMEIDA CHUFFA¹, LEóN FERDER², FELIPE INSERRA², WALTER MANUCHA^3,4,*

BIOCELL, Vol.48, No.10, pp. 1429-1442, 2024, DOI:10.32604/biocell.2024.053478 - 02 October 2024

Abstract The interplay between mitochondria, epigenetics, and the microbiota is intricately linked to both health and disease. Within our cells, a complex molecular dance occurs, where these components intertwine in a mesmerizing ballet that plays a decisive role in our health. Mitochondria, beyond being energy powerhouses, modulate nuclear gene expression through messengers like reactive oxidative stress (ROS) and calcium. Epigenetics, acting as the molecular conductor, regulates the expression of both nuclear and mitochondrial genes through modifications like DNA methylation. The intestinal microbiota itself produces short-chain fatty acids (SCFAs) that influence mitochondrial activity. SCFA-induced epigenetic modifications, like… More >

Chaoying Wang¹, Lihui Ma², Yingzan Xie², Bo Ding³, Jingsi Huang⁴, Qian Wang^4,*

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1981-1993, 2024, DOI:10.32604/phyton.2024.050099 - 30 August 2024

Abstract Myricaria laxiflora, which grows along the Yangtze River in China, holds ornamental, ecological, and medicinal value. However, its wild population is threatened and currently designated protected as a national priority. The present research was the first to sequence and assemble M. laxiflora’s mitochondrial genome and examine its structural characteristics and phylogenetic relationships with other sequenced Caryophyllales species. The mitochondrial double-stranded closed-ring genome of M. laxiflora was found to be 389,949 bp in length, containing numerous repetitive sequences and RNA editing sites, with 34 protein encoding, 21 tRNA, and 3 rRNA genes. Although there are 22 fragments in the More >

TINGTING LIU^#, DINGYOU GUO^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.8, pp. 1155-1179, 2024, DOI:10.32604/biocell.2024.051518 - 02 August 2024

Abstract In China, Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative illness affecting middle-aged and older persons. Movement disorders including resting tremor, bradykinesia, myotonia, postural instability, and gait instability are the predominant clinical symptoms. The two main types of PD are sporadic and familial, with sporadic PD being the more prevalent of the two. The environment, genetics, mitochondrial dysfunction, oxidative stress, inflammation, protein aggregation and misfolding, loss of trophic factors, cell death, and gut microbiota may all have a role in the etiology of PD. PD is inversely connected with other More >

DAIXIN ZHAO¹, QINGYU WANG², JIANBO WANG^1,*

BIOCELL, Vol.48, No.2, pp. 271-281, 2024, DOI:10.32604/biocell.2023.029094 - 23 February 2024

Abstract Background: Esophageal cancer (ESCA) is a common digestive tract tumor. As a result, optimization of the early diagnosis of ESCA and identifying the contributing prognostic genes is urgently required. Herein, the prognosis of mitochondrial autophagy-related genes was analyzed in different subtypes of ESCA, and prognostic models were constructed to identify the immune cell infiltration with significant differences between subtypes. Methods: The Cancer Genome Atlas database was searched to download 185 ESCA samples, covering gene expression level data and clinical follow-up data, and 179 samples from the Gene Expression Omnibus database for subsequent validation analysis. The… More >

YUANYUAN XU, XIAOKE CHEN^*

Oncology Research, Vol.32, No.3, pp. 517-528, 2024, DOI:10.32604/or.2023.030293 - 06 February 2024

Abstract Background: The aberrant intracellular expression of a mitochondrial aspartyl-tRNA synthetase 2 (DARS2) has been reported in human cancers. Nevertheless, its critical role and detailed mechanism in lung adenocarcinoma (LUAD) remain unexplored. Methods: Initially, The Cancer Genome Atlas (TCGA)-based Gene Expression Profiling Interactive Analysis (GEPIA) database () was used to analyze the prognostic relevance of DARS2 expression in LUAD. Further, cell counting kit (CCK)-8, immunostaining, and transwell invasion assays in LUAD cell lines in vitro, as well as DARS2 silence on LUAD by tumorigenicity experiments in vivo in nude mice, were performed. Besides, we analyzed the expression levels… More >

POOJA JAISWAL¹, VERSHA TRIPATHI¹, ANSHUL ASSAIYA², DHARMENDRA KASHYAP³, RAHUL DUBEY⁴, ANAMIKA SINGH⁴, JANESH KUMAR², HEM CHANDRA JHA³, RAJESH SHARMA⁵, AMIT KUMAR DIXIT⁶, HAMENDRA SINGH PARMAR^1,*

BIOCELL, Vol.46, No.12, pp. 2645-2657, 2022, DOI:10.32604/biocell.2022.021754 - 10 August 2022

Abstract Triple-negative breast cancer (TNBC) cell line MDA-MB-231 is known for Warburg metabolism and defects in mitochondria. On the other hand, dipeptidyl peptidase-IV (DPP-IV) inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis, but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell line. We have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase (AMPK), which activates the downstream transcription factors PGC-1α, PGC-1β, or FOXO1 for mitochondrial biogenesis; above-mentioned incretin-based… More >

XINLU GAO^1,2,#, XIUXIU WANG^1,2,#, WENWEN ZHANG^1,2,#, HANJING LI^1,2, FAN YANG^2,3, WENYA MA², YU LIU^1,*

BIOCELL, Vol.46, No.12, pp. 2637-2644, 2022, DOI:10.32604/biocell.2022.021033 - 10 August 2022

Abstract Photobiomodulation (PBM) has been shown to delay the pathological process of heart failure, but the exact mechanism of action is not clear. Mitochondria occupy one-third of the volume of mammalian cardiomyocytes (CMs) and are central transport stations for CM energy metabolism. Therefore, in this study, we explored the regulatory effects of 630 nm light-emitting diodes (LED-Red) on the mitochondria of CMs. The results show that LED-Red-based PBM promotes adenosine triphosphate (ATP) synthesis by upregulating the expression of glycolipid metabolizing enzymes. Correspondingly, there was an improvement in the activity of succinate dehydrogenase (SDH), a key enzyme… More >

Muhammad Umar Nasir¹, Muhammad Adnan Khan^1,2, Muhammad Zubair³, Taher M. Ghazal^4,5, Raed A. Said⁶, Hussam Al Hamadi^7,*

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 953-963, 2022, DOI:10.32604/cmc.2022.028958 - 18 May 2022

Abstract One of the most difficult jobs in the post-genomic age is identifying a genetic disease from a massive amount of genetic data. Furthermore, the complicated genetic disease has a very diverse genotype, making it challenging to find genetic markers. This is a challenging process since it must be completed effectively and efficiently. This research article focuses largely on which patients are more likely to have a genetic disorder based on numerous medical parameters. Using the patient’s medical history, we used a genetic disease prediction algorithm that predicts if the patient is likely to be diagnosed… More >

ZHENGGANG XU^1,2,3, LIANG WU³, JIAHAO CHEN¹, YUNLIN ZHAO³, CHONGXUAN HAN¹, TIAN HUANG², GUIYAN YANG^1,*

BIOCELL, Vol.46, No.7, pp. 1733-1746, 2022, DOI:10.32604/biocell.2022.015784 - 17 March 2022

Abstract Darwin’s finches are the most classic case of evolution. Early studies on the evolution of this species were mainly based on morphology. Until now, the mitochondrial genome of Geospiza magnirostris has been sequenced and the study explored the characteristics of the complete genome of G. magnirostris and verified the evolutionary position of it. The 13 PCGs initiated by ATN codons. The stop codons of three PCGs (ND2, COX3 and ND4) were incomplete, with only T- or TA- replacing complete form TAA or TAG. All the tRNA genes expressed a typical cloverleaf secondary structure, except for tRNA^Ser1(AGY), whose dihydrouridine (DHU)… More >