Sumayh S. Aljameel¹, Malak Aljabri^1,2, Nida Aslam¹, Dorieh M. Alomari^3,*, Arwa Alyahya¹, Shaykhah Alfaris¹, Maha Balharith¹, Hiessa Abahussain¹, Dana Boujlea¹, Eman S. Alsulmi⁴

CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1291-1304, 2023, DOI:10.32604/cmc.2023.035710 - 06 February 2023

Abstract Currently, the risk factors of pregnancy loss are increasing and are considered a major challenge because they vary between cases. The early prediction of miscarriage can help pregnant ladies to take the needed care and avoid any danger. Therefore, an intelligent automated solution must be developed to predict the risk factors for pregnancy loss at an early stage to assist with accurate and effective diagnosis. Machine learning (ML)-based decision support systems are increasingly used in the healthcare sector and have achieved notable performance and objectiveness in disease prediction and prognosis. Thus, we developed a model… More >

Tarek A ATIA

BIOCELL, Vol.43, No.4, pp. 253-262, 2019, DOI:10.32604/biocell.2019.08180

Abstract Recurring miscarriage (RM) is a frustrating reproductive complication with variable etiology. Numerous genetic defects have been known to play a crucial role in the etiology of RM. Chromosomal abnormalities are frequently detected, while other genetic defects cannot be diagnosed through routine research, such as cryptic chromosomal anomalies, single nucleotide polymorphism, single-gene defect, and gene copy number variation. Diagnostic laboratories have recently used variable advanced techniques to detect potential genetic abnormalities in couples with RM and/or in products of conception. Here we aim to summarize the known genetic causes of RM, with a focus on the More >

Safia Messaoudi¹, Ghada M. Al-Khateeb², Maryam Dendana¹, Mai S. Sater², Khaled B. Jazia³, Mounia Nouira⁴, Wassim Y. Almawi², Touhami Mahjoub¹

European Cytokine Network, Vol.22, No.2, pp. 123-126, 2011, DOI:10.1684/ecn.2011.0287

Abstract Objectives. Insofar as recurrent spontaneous miscarriage (RSM) is linked with dysregulated immunity and inflammatory changes, and given the pro-inflammatory role of interleukin-21 (IL-21), we examined the association between IL-21 polymorphisms and RSM. Methods and results. IL-21 rs2055979, rs13143866, rs9992580, and rs4833837 were genotyped in 235 cases of RSM and 235 controls. Regression analysis was employed in assessing the contribution of IL-21 variants to the overall RSM risk. Higher minor allele and genotype frequencies of rs2055979 and rs13143866, but not rs9992580 or rs4833837, were seen in RSM patients than in the controls. IL-21 haplotype [rs9992580/rs4833837/rs2055979/rs13143866] analysis More >