YU LU¹, TSUTOMU MIYAMOTO^1,*, HODAKA TAKEUCHI¹, FUMI TSUNODA¹, NAOKI TANAKA^2,3,4, TANRI SHIOZAWA¹

Oncology Research, Vol.31, No.3, pp. 239-253, 2023, DOI:10.32604/or.2023.026067

Abstract Endometrial carcinoma (EMC) is associated with obesity; however, the underlying mechanisms have not yet been elucidated. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that is involved in lipid, glucose, and energy metabolism. PPARα reportedly functions as a tumor suppressor through its effects on lipid metabolism; however, the involvement of PPARα in the development of EMC remains unclear. The present study demonstrated that the immunohistochemical expression of nuclear PPARα was lower in EMC than in normal endometrial tissues, suggesting the tumor suppressive nature of PPARα. A treatment with the PPARα activator, irbesartan, inhibited the EMC cell lines, Ishikawa and… More >

GUANQIONG HU¹, RISHENG HUANG², LUELUE LU¹, QINSHI PAN³, XIAOXIN CHEN^1,*

BIOCELL, Vol.47, No.6, pp. 1243-1251, 2023, DOI:10.32604/biocell.2023.027763

Abstract Background: Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that plays a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). While previous studies have revealed a cross-talk between vitamin D and TGF-β1 signaling, it is still unclear how they interact with each other to regulate the progression of IPF. Methods: In this work, we searched for a novel mediator of TGF-β1 activity in lung fibroblasts and examined its regulation by vitamin D. In addition, we investigated the mechanism underlying the interaction between vitamin D and TGF-β1 signaling in lung fibroblast activation. Bioinformatic analysis was performed to identify TGF-β1… More >

Sujie Shao, Shihan Tian^*, Shaoyong Guo, Xuesong Qiu

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 4867-4891, 2023, DOI:10.32604/cmc.2023.038280

Abstract Internet of Vehicles (IoV) applications integrating with edge computing will significantly drive the growth of IoV. However, the contradiction between the high-speed mobility of vehicles, the delay sensitivity of corresponding IoV applications and the limited coverage and resource capacity of distributed edge servers will pose challenges to the service continuity and stability of IoV applications. IoV application migration is a promising solution that can be supported by application containerization, a technology forseamless cross-edge-server application migration without user perception. Therefore, this paper proposes the container-based IoV edge application migration mechanism, consisting of three parts. The first is the migration trigger determination… More >

WEI XIA¹, NING YANG², XIAOYAN FENG³, TING XIN¹, YONGLE JING¹, YUMING LI^4,*, CHENGZHI LU^1,5,*

BIOCELL, Vol.47, No.4, pp. 837-847, 2023, DOI:10.32604/biocell.2023.026161

Abstract Background: Preeclampsia (PE), characterized by hypertension and proteinuria, leads to serious maternal and infant complications. Uridine-cytidine kinase 2 (UCK2) belongs to the UCK family, a class of enzymes that catalyzes the conversion of uridine and cytidine to monophosphate form. However, the role of UCK2 in PE has not been reported. Methods: The expression of UCK2 was detected in the placenta of PE patients and N(ω)-nitro-L-arginine methyl esterinduced PE mouse model. Through forced up-regulation or down-regulation of UCK2 in vitro, we examined the effects of UCK2 on the proliferation, apoptosis, migration, and invasion of trophoblast cells. Stattic, the inhibitor of STAT3… More >

JINGYAO XU^1,#, SHUANGLI HAO^1,#, KAIYUE HAN^1,#, WANXI YANG^1,*, HONG DENG^2,*

BIOCELL, Vol.47, No.4, pp. 773-788, 2023, DOI:10.32604/biocell.2023.026618

Abstract As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer patients, most deaths are caused by the growth of metastatic tumors outside the primary focus. Therefore, migration and invasion in the late stage of tumor progression are the main unresolved issues in the study of tumor pathogenesis, and AKT/mTOR has been found to participate in the migration and invasion of cancer cells, which means that the study of this pathway may contribute to a solution for the problem. Because of… More >

XIAOSU SONG, FEN GAO, HONG LI, WEIWEI QIN, CHANJUAN CHAI, GUOJUAN SHI, HUIYU YANG^*

BIOCELL, Vol.47, No.4, pp. 849-858, 2023, DOI:10.32604/biocell.2023.026545

Abstract Background: Vascular smooth muscle cells (VSMCs) undergo a conversion from a contractile phenotype to a proliferative synthetic phenotype, contributing to the pathogenesis of cardiovascular diseases. Semaphorin 7A (SEMA7A) is a glycosylphosphatidylinositol-anchored membrane protein that plays an important role in vascular homeostasis by regulating endothelial cell behaviors. However, the expression and role of SEMA7A in VSMCs remain unclear.Methods: In this study, we screened for VSMC-regulating genes in publicly available datasets and analyzed the expression of SEMA7A in human coronary artery smooth muscle cells (hCASMCs) treated with platelet-derived growth factor-BB (PDGF-BB). The effects of SEMA7A overexpression and knockdown on hCASMC proliferation and… More >

GANG WANG^#, MINGPING QIAN^#, WEI JIAN, JUHANG CHU, YIXIANG HUANG^*

Oncology Research, Vol.31, No.1, pp. 63-70, 2023, DOI:10.32604/or.2022.028168

Abstract Circular RNA (circRNA), as a newly discovered non-coding RNA with important regulatory potential, is closely related to the occurrence and progression of various tumors. This study aimed to investigate has_circ_0000069 expression in breast cancer and its influence on cellular activities. Using real-time quantitative polymerase chain reaction, has_circ_0000069 levels were measured in 137 pairs of tissue specimens, as well as cancer cell lines. The cellular activities of cell lines were determined by cell counting kit-8 (CCK-8) and Transwell assays. The potential targeting miRNAs were predicted and verified using an online database and dual-luciferase reporter assay. Has_circ_0000069 was highly expressed in breast… More >

Wei Xiong^1,2, Dagang Li^1,*, Peixing Wei², Lin Wang², Qian Feng¹

Journal of Renewable Materials, Vol.11, No.5, pp. 2265-2278, 2023, DOI:10.32604/jrm.2023.025483

Abstract Poplar wood, which was used as the absorption material for the solar-driven interfacial evaporation, was treated for 3 days, 6 days and 9 days with the pectinase, and then was simulated for photothermal evaporation test at one standard solar radiation intensity (1 kW⋅m⁻²). The effects of pectinase treatment on cell passage and water migration capacity of poplars were analyzed by the mercury intrusion porosimetry, the scanning electron microscope and fractal theory. It was found that the pit membrane and the ray parenchyma cells of poplar wood were degraded and destroyed after pectinase treatment. Compared with the untreated poplar wood, the evaporation… More >

Linpei Wang^1,#, Xiaoqiu Ma^2,#, Youqi Chen¹, Jiahui Zhang¹, Jiawei Zhang¹, Wei Wang^1,*, Shaojian Chen^3,*

Oncologie, Vol.24, No.4, pp. 897-912, 2022, DOI:10.32604/oncologie.2022.025693

Abstract Background: MicroRNA-145-5p (miR-145-5p) reportedly inhibits hepatocellular carcinoma (HCC) by targeting ARF6, SPATS2, CDCA3, KLF5, and NRAS, indicating that miR-145-5p plays an important role in the occurrence and development of HCC by regulating the expression of various genes. In this study, we aimed to explore novel downstream targets of miR-145-5p and elucidate the potential mechanism of miR-145-5p in HCC. Materials and Methods: A bioinformatics analysis was performed to determine the clinical significance of miR-145-5p and alpha/beta hydrolase domain-containing protein 17C (ABHD17C) in patients with HCC. The ability of Hep3B cells to proliferate, migrate, and invade was examined after overexpression of miR-145-5p… More >

Tahir Alyas¹, Taher M. Ghazal^2,3, Badria Sulaiman Alfurhood⁴, Munir Ahmad⁵, Ossma Ali Thawabeh⁶, Khalid Alissa⁷, Qaiser Abbas^8,*

CMC-Computers, Materials & Continua, Vol.74, No.3, pp. 6289-6305, 2023, DOI:10.32604/cmc.2023.035161

Abstract In the cloud environment, the transfer of data from one cloud server to another cloud server is called migration. Data can be delivered in various ways, from one data centre to another. This research aims to increase the migration performance of the virtual machine (VM) in the cloud environment. VMs allow cloud customers to store essential data and resources. However, server usage has grown dramatically due to the virtualization of computer systems, resulting in higher data centre power consumption, storage needs, and operating expenses. Multiple VMs on one data centre manage share resources like central processing unit (CPU) cache, network… More >