Lihua Jiang*1,
Wenchuan Yang*1,
Weishi Bian†, Hailin Yang*, Xia Wu*, Yuhua Li*,
Wen Feng*, Xuejian Liu*
Oncology Research, Vol.27, No.1, pp. 19-27, 2019, DOI:10.3727/096504018X15193469240508
Abstract The dysregulation of microRNAs (miRNAs) plays an important function in the onset and progression of gastric
cancer (GC). In addition, aberrantly expressed miRNAs affect the chemosensitivity of GC cells to chemotherapeutic drugs. Hence, miRNA-based targeted therapy might be applied to treat patients with GC exhibiting chemotherapeutic resistance. In this study, miRNA-623 (miR-623) expression was downregulated in GC tissues
and cell lines. Functional analysis showed that the restored miR-623 expression could inhibit the proliferation
of GC cells and enhance their chemosensitivity to 5-FU via the cell apoptosis pathway. Cyclin D1 (CCND1)
was identified as a direct More >
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