Ning Wang*1, Yang Zhang†1, Huaxin Liang‡
Oncology Research, Vol.26, No.8, pp. 1275-1283, 2018, DOI:10.3727/096504018X15185735627746
Abstract The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor
development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was
significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell
proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1
(MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory
effects of miR-598 overexpression on GBM cells. In addition, miR-598 overexpression suppressed Met/
AKT pathway activation in GBM. Our results provided compelling evidence that miR-598 serves More >
Login
Register
