Jihong Sun*†1, Jingjing Li‡1, Weiguo Zhang*, Juan Zhang*, Shenjie Sun*, Guiqi Li*, Hengliang Song*, Daguo Wan*
Oncology Research, Vol.25, No.3, pp. 455-461, 2017, DOI:10.3727/096504016X14747283032017
Abstract Gastric cancer (GC) is the fourth most common cancer globally. Recently, microRNAs (miRNAs) have been
suggested to be closely associated with tumorigenesis. Aberrant expression of miR-509-3p has been reported in
cancer studies. However, the expression and mechanism of its function in GC remain unclear. Here we showed
that miR-509-3p was downregulated in GC specimens, which was associated with overall survival. Functional
investigations demonstrated that the overexpression of miR-509-3p inhibited the migration and proliferation
of the GC cells. Additionally, we identified X-linked inhibitor of apoptosis protein (XIAP) as a direct target of
miR-509-3p. Knockdown of XIAP More >
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