Zhiling Zhang, Jiawei Wang, Runfang Gao, Xuan Yang, Yafen Zhang, Jie Li, Jing Zhang, Xingjuan Zhao, Chunfang Xi, Xiaoting Lu
Oncology Research, Vol.25, No.5, pp. 753-761, 2017, DOI:10.3727/096504016X14772342320617
Abstract Our study aimed to investigate whether microRNA-449 (miR-449) plays a key role in regulating the migration
and invasion of breast cancer cells via targeting tumor protein D52 (TPD52). The results of the qRT-PCR and
Western blotting showed that, in comparison with normal breast tissues and cells, miR-449 was significantly
downregulated in breast cancer tissues and cells, while TPD52 was markedly upregulated. After transfection
with an miR-449 inhibitor, suppression of miR-449 significantly promoted cell migration and invasion. Also,
when miR-449 was overexpressed by transfection with miR-449 mimics, E-cadherin expression significantly
increased, and the expression of N-cadherin More >
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