Bo Xia*, Lei Wang†, Li Feng*, Baofang Tian*, Yuanjie Tan‡, Baoyin Du*
Oncology Research, Vol.27, No.1, pp. 89-98, 2019, DOI:10.3727/096504018X15199511344806
Abstract Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study
aimed to explore the effects of long noncoding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma
cell proliferation, migration, invasion, and apoptosis, as well as the underlying potential mechanism. We found
that CAT104 was highly expressed in osteosarcoma MG63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration, and invasion, but promoted cell apoptosis. CAT104
regulated the expression of miR-381, and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc
finger E-box-binding homeobox 1 (ZEB1) was a direct target gene of… More >
Login
Register
