Xi Shi*1, Xiao Xiao†1, Na Yuan*, Shili Zhang*, Fukang Yuan‡, Xiaohong Wang§
Oncology Research, Vol.26, No.7, pp. 987-996, 2018, DOI:10.3727/096504017X15140534417184
Abstract Cervical cancer is the fourth most common malignancy among females worldwide. MicroRNA-379 (miR-379)
is aberrantly expressed in multiple human cancer types. However, the expression pattern, roles, and detailed
regulatory mechanisms of miR-379 in cervical cancer remain unknown. In this study, we found that miR-379
expression was downregulated in cervical cancer tissues and cell lines. Low miR-379 expression was correlated with International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and
distant metastasis. Additionally, miR-379 overexpression suppressed the proliferation and invasion of cervical
cancer cells. Furthermore, V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) More >
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