Cong Ye*, Yubo Hu†, Junrong Wang*
Oncology Research, Vol.27, No.2, pp. 183-192, 2019, DOI:10.3727/096504018X15201124340860
Abstract A large number of microRNAs (miRNAs) are aberrantly expressed in cervical cancer and play crucial roles in
the onset and progression of cervical cancer by acting as either an oncogene or a tumor suppressor. Therefore,
investigation of the expression, biological roles, and underlying mechanisms of miRNAs in cervical cancer
might provide valuable therapeutic targets in the treatment for patients with this disease. In this study, miRNA-
377 (miR-377) was downregulated in cervical cancer tissues and cell lines. Decreased miR-377 expression was
strongly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node
metastasis, and distant metastasis in… More >
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