Zhixian Guo*1, Jingjing Li*1, Jihong Sun†, Lu Sun†, Yubing Zhou‡, Zujiang Yu*
Oncology Research, Vol.26, No.7, pp. 1073-1081, 2018, DOI:10.3727/096504017X15145088802439
Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. MicroRNA
(miRNA), a class of noncoding single-stranded RNA molecules, is involved in regulating cancer cell proliferation, metastasis, migration, invasion, and apoptosis. We showed that the expression of miR-346 was significantly increased in HCC tissues and cell lines, compared with noncancerous controls, and was associated with
poor prognosis. Overexpression of miR-346 promoted proliferation and inhibited apoptosis of SMMC-7721
cells, while knockdown of miR-346 significantly suppressed proliferation and induced apoptosis of HepG2
cells. Then we identified breast cancer metastasis suppressor 1 (BRMS1) as a direct More >
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