Quan Shi*†, Qi He*, Jing Wei*
Oncology Research, Vol.26, No.9, pp. 1447-1455, 2018, DOI:10.3727/096504018X15193823766141
Abstract As documented in numerous studies, microRNAs (miRNAs) play key roles in various biological processes
associated with melanoma occurrence and development. In this study, we found that miRNA-342 (miR-342)
was significantly downregulated in melanoma tissues and cell lines. Additionally, the ectopic expression of
miR-342 prohibited the cell proliferation and invasion of melanoma. Moreover, zinc-finger E-box-binding
homeobox 1 (ZEB1) was identified as a direct target gene of miR-342 in melanoma. Similar with the results
induced by miR-342 overexpression, ZEB1 knockdown attenuated cell proliferation and invasion in melanoma.
Furthermore, the restoration of ZEB1 expression reversed the suppressive effects More >
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