Li Chen, Guozhang Ma, Xiaohui Cao, Xiaoxia An, Xiguang Liu
Oncology Research, Vol.26, No.9, pp. 1429-1437, 2018, DOI:10.3727/096504018X15186047251584
Abstract Melanoma is characterized by aggressive invasion, early metastasis, and resistance to existing chemotherapeutic agents. Accumulated studies have reported that microRNA (miRNA) is a potentially robust molecular tool
for developing future therapeutic technologies. Therefore, examining the expression patterns, biological roles,
and associated mechanisms of cancer-related miRNAs in melanoma is essential for developing novel therapeutic targets for patients with this disease. In this study, miRNA-331 (miR-331) was underexpressed in melanoma
tissues and cell lines. Functional assays revealed that the enforced expression of miR-331 inhibited cell proliferation and invasion. In addition, astrocyte-elevated gene-1 (AEG-1) was identified as a More >
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