Huiling Wang*, Xin Hu†, Feng Yang‡, Hui Xiao*
Oncology Research, Vol.28, No.7-8, pp. 731-744, 2020, DOI:10.3727/096504020X16100888208039
Abstract This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer
(BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell
lines, and the expression of S100A2 was significantly decreased. Also, the high level of miR-325-3p was
closely associated with low expression of S100A2 in BC tissues. Moreover, introduction of miR-325-3p significantly promoted proliferation, invasion, and EMT of BC cells. Bioinformatics analysis predicted that the
S100A2 was a potential target gene of miR-325-3p. Luciferase reporter assay demonstrated that miR-325-3p
could directly target S100A2. In addition, miR-325-3p overexpression… More >
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