Ruoyu Wang*†, Heming Li†, Xuefen Guo†, Zhe Wang†, Shanshan Liang†, Chengxue Dang*
Oncology Research, Vol.24, No.4, pp. 225-231, 2016, DOI:10.3727/096504016X14648701447931
Abstract Recurrence and distant metastasis are the most common cause of therapeutic failure in nasopharyngeal carcinoma (NPC) patients. Insulin-like growth factor I (IGF-I) can induce epithelial-to-mesenchymal transition
(EMT) in many epithelial tumors; however, whether IGF-I can enhance NPC metastasis by EMT and the
mechanisms remain unclear. Herein, we have identified that IGF-I could induce EMT and enhance migration
ability in NPC cell lines. Furthermore, both Src inhibitor and microRNA-30a (miR-30a) inhibitor reversed
IGF-I-induced EMT, suggesting the involvement of an IGF-IR–Src–miR-30a–E-cadherin pathway in IGF-Iinduced EMT in NPC cell lines. Overall, the results of the present study may More >
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