Hui Zhou*†, Yanglin Liu†, Ling Xiao‡, Zhengmao Hu*, Kun Xia*§
Oncology Research, Vol.25, No.1, pp. 147-154, 2017, DOI:10.3727/096504016X14732772150505
Abstract MicroRNA-27b (miR-27b) was recently found to be significantly downregulated in different human cancers.
However, evidence of the function of miR-27b in non-small cell lung cancer (NSCLC) remains limited. In
this study, we aimed to investigate novel miR-27b-mediated targets or signaling pathways associated with the
tumorigenesis and metastasis of NSCLC. Real-time (RT) PCR was performed to examine miR-27b expression
in NSCLC specimens. MTT assay, wound-healing assay, and Transwell assay were used to determine cell
proliferation, migration, and invasion. Our data indicated that the miR-27b levels were significantly decreased
in NSCLC specimens and cell lines (SK-MES-1, H358,… More >
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