Nan Li*†, Hangyu Shi†, Lu Zhang‡, Xu Li§, Lu Gao†, Gang Zhang†, Yongqiang Shi†, Shiwen Guo*
Oncology Research, Vol.26, No.5, pp. 785-794, 2018, DOI:10.3727/096504017X15127309628257
Abstract MicroRNAs (miRNAs) play important roles in several human cancers. Although miR-188 has been suggested
to function as a tumor repressor in cancers, its precise role in glioma and the molecular mechanism remain
unknown. In the present study, we investigated the effect of miR-188 on glioma and explored its relevant
mechanisms. We found that the expression of miR-188 is dramatically downregulated in glioma tissues and
cell lines. Subsequent investigation revealed that miR-188 expression was inversely correlated with β-catenin
expression in glioma tissue samples. Using a luciferase reporter assay, β-catenin was determined to be a direct
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