Weichen Hou*, Lei Song†, Yang Zhao*, Qun Liu*, Shuyan Zhang‡
Oncology Research, Vol.28, No.7-8, pp. 815-818, 2020, DOI:10.3727/096504021X16240202939988
Abstract The role of miRNAs in the radiosensitivity of glioma cells and the underlying mechanism is still far from
clear. In the present study, we detected six downregulated and seven upregulated miRNAs in the serum after
radiotherapy compared with paired serum samples before radiotherapy via miRNA panel PCR. Among these,
miR-17-5p was highly reduced (fold change = −4.21). Further, we validated the levels of miR-17-5p in all
serum samples with qRT-PCR. In addition, statistical analysis suggested that a reduced miR-17-5P level was
positively associated with advanced clinical stage of glioma, incidence of relapse, and tumor differentiation.
Moreover, we provided evidence that… More >
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