Wei-Zhen Liu, Nian Liu
Oncology Research, Vol.27, No.1, pp. 1-8, 2019, DOI:10.3727/096504018X15172738893959
Abstract Propofol has been widely used in lung cancer resections. Some studies have demonstrated that the effects
of propofol might be mediated by microRNAs (miRNAs). This study aimed to investigate the effects and
mechanisms of propofol on lung cancer cells by regulation of miR-1284. A549 cells were treated with different
concentrations of propofol, while transfected with miR-1284 inhibitor, si-FOXM1, and their negative controls.
Cell viability, migration, and invasion, and the expression of miR-1284, FOXM1, and epithelial–mesenchymal
transition (EMT) factors were detected by CCK-8, Transwell, qRT-PCR, and Western blot assays, respectively.
In addition, the regulatory and binding relationships among propofol, miR-1284, and… More >
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