Lulin Zhang, Jun Yao, Wenyao Li, Ce Zhang
Oncology Research, Vol.26, No.6, pp. 827-836, 2018, DOI:10.3727/096504017X14934840662335
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths due to its highly
aggressive biological nature and resistance to chemotherapy. Previous studies indicate that miR-21 is an important regulator in the activation of cancer-associated fibroblasts (CAFs). However, whether miR-21 in CAFs
would regulate PDAC’s tumor microenvironment and lead to drug resistance remain unknown. In this study,
we evaluated the relationship between CAF activation, miR-21 expression, and drug resistance using tumor
samples from PDAC patients. We changed the miR-21 expression level in CAFs and tested its roles in regulating the function of… More >
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