Yueli Gu*, Jinchun Si†, Xichun Xiao*, Ying Tian*, Shuo Yang*
Oncology Research, Vol.25, No.7, pp. 1069-1079, 2017, DOI:10.3727/096504016X14829256525028
Abstract Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of miR-92a in acute myeloid leukemia (AML) remain to be elucidated. Our data showed
that miR-92a was evidently downregulated and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) was
remarkably upregulated in AML cell lines HL-60 and THP-1. Dual luciferase reporter assay revealed that
MTHFD2 was a direct target of miR-92a. Gain- and loss-of-function analysis demonstrated that MTHFD2
knockdown or miR-92a overexpression notably inhibited proliferation and promoted apoptosis of AML cell
lines. Restoration of MTHFD2 expression reversed proliferation inhibition and apoptosis induction of More >
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