Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Yongle Qiu^1,#, Kunshan Li^1,#, Wenjing Wang¹, Wenjuan Zhang², Jilun Liu², Yang Bai³, Fei Xu³, Jie Guo^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069612 - 30 December 2025

Abstract Background: The regulatory mechanisms governing vasculogenic mimicry (VM) in oral squamous cell carcinoma (OSCC) remain largely undefined. This study aimed to identify critical factors and elucidate the epigenetic mechanisms underlying VM in OSCC. Methods: Bioinformatics analysis was performed utilizing single-cell RNA-seq, bulk RNA-seq, and histone H3 lysine 27 acetylation (H3K27ac) Chromatin Immunoprecipitation (ChIP)-seq data obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. ChIP-qPCR was used to validate the binding of ETS transcription factor ELK4 (ELK4) to the dihydrofolate reductase (DHFR) enhancer. In vitro VM formation and invasion of OSCC cells were… More > Graphic Abstract

Wendong Jia^#, Ting Zhang^#, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang^*, Ni Yin^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068651 - 30 December 2025

Abstract Objectives: Chromobox 4 (CBX4), a polycomb protein family member linked to tumor pathogenesis via dysregulation, has an incompletely defined role in gastric cancer (GC). The study aimed to investigate the role and mechanism of CBX4 in GC progression and evaluate its potential as a therapeutic target. Methods: CBX4 expression was assessed in GC tissues vs. adjacent non-cancerous tissues and in GC cell lines vs. normal gastric mucosal epithelial cells. Clinicopathological correlations were analyzed. Functional impacts of CBX4 were determined using knockdown and overexpression models in vitro (cell proliferation, migration, invasion) and in vivo (xenograft tumorigenesis in nude… More >

Yan Gui^1,#, Wen Pan^1,#, Ziyi Dong^1,#, Dongzhi Hu^1,#, Yaoyang Guo¹, Xinyi Wen¹, Haiyang Zhang², Zhansheng Jiang^1,*, Xiangqian Zheng^1,*, Ming Gao^2,*, Junyi Wang^1,*

Oncology Research, Vol.33, No.12, pp. 3991-4011, 2025, DOI:10.32604/or.2025.067182 - 27 November 2025

Abstract Objectives: Metastatic spread to the lung is one of the leading causes of fatal outcomes in thyroid cancer, but the underlying molecular mechanisms remain unclear. To investigate how exosomal microRNA-17-5p (miR-17-5p) promotes lung metastasis in thyroid cancer within the framework of the “seed and soil” hypothesis. Methods: Serum exosomes from thyroid cancer lung metastasis patients and controls were analyzed for miR-17, which was elevated in metastatic cases. miR-17 was transfected into embryonic lung fibroblasts (MRC-5), and their supernatants were co-cultured with thyroid cancer cells (Cal62). Cell proliferation and migration were evaluated using colony formation, Ki67… More >

Ana Clara Ciglioni Salustiano^1,2, Gabriela Barbosa^1,3,4, Rodolfo Borges dos Reis^2,4, Amílcar Castro de Mattos^5,6, Athanase Billis⁶, Leonardo O. Reis^1,3,4,*

Oncology Research, Vol.33, No.11, pp. 3417-3428, 2025, DOI:10.32604/or.2025.068023 - 22 October 2025

Abstract Objective: The tumor microenvironment plays a pivotal role in prostate cancer progression and may differ across metastatic sites. This study aimed to evaluate and compare the primary and metastatic prostate adenocarcinoma tumor microenvironment. Methods: A total of 27 formalin-fixed paraffin-embedded tissue samples derived from 17 patients diagnosed with prostate adenocarcinoma, including the primary tumors, and the corresponding metastatic lymphatic and hematogenous lesions from various anatomical sites. Immunohistochemical labeling was performed using antibodies against Cluster of Differentiation 3 epsilon chain (CD3e), CD8 alpha chain (CD8a), Cluster of Differentiation 68 (CD68), Cluster of Differentiation 163 (CD163), Forkhead… More > Graphic Abstract

Jun Li^1,#, Yang Chen^1,#, Zhijiao Hao², Zhiyong Zhang³, Jingyi Fan¹, Xiao Liu¹, Xueli Zhao³, Hongyan Zhang⁴, Chenpeng Wu^3,*

Oncology Research, Vol.33, No.11, pp. 3523-3541, 2025, DOI:10.32604/or.2025.067535 - 22 October 2025

Abstract Background: Radiation sensitive 23 homolog B (RAD23B), a DNA repair-related protein, plays a contributory role in the development of multiple malignancies. This study aimed to explore the role of RAD23B in promoting colorectal cancer (CRC) metastasis and to elucidate the underlying molecular mechanisms. Methods: RAD23B was overexpressed in CRC cell lines SW480 and HCT-8, with empty vectors serving as controls. Invasion, cell proliferation, and migration were assessed using CCK-8 and Transwell assays. A xenograft mouse model was used to evaluate metastatic potential in vivo. Immunoprecipitation-mass spectrometry (IP-MS) and transcriptomic analysis by RNA sequencing (RNA-seq) were performed… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.10, pp. 3159-3159, 2025, DOI:10.32604/or.2025.073035 - 26 September 2025

Abstract This article has no abstract. More >

Wenjing Liao^1,#, Liaodi Wang^2,#, Zhen Huang¹, Ziyu Zou¹, Yimin Liu¹, Haoyue Liu¹, Zhaoning Duan¹, Liangdan Tang^1,*

Oncology Research, Vol.33, No.10, pp. 3041-3064, 2025, DOI:10.32604/or.2025.065451 - 26 September 2025

Abstract Objectives: Ovarian cancer (OC) is a highly heterogeneous disease characterized by high metastatic potential and frequent recurrence. 3β-hydroxysterol Δ24-reductase (DHCR24) is closely associated with the progression of various malignant tumors, but its role in OC remains unexplored. This study is the first to systematically investigate the function of DHCR24 in OC and elucidate its mechanism in promoting OC progression, providing novel theoretical insights for targeted therapy. Methods: The expression of DHCR24 was evaluated in tissues using bioinformatics and clinical data; the impact of DHCR24 on the malignant behavior of OC was assessed through in vivo and in… More >

Siddharth Marthi^1,*, Muhammad Mukarram¹, Fatemeh Ardeshir-Larijani², Lara Rabih Harik³, Shreyas Subhash Joshi^1,2

Canadian Journal of Urology, Vol.32, No.4, pp. 349-353, 2025, DOI:10.32604/cju.2025.063775 - 29 August 2025

Abstract Tumor-to-tumor metastasis (TTM) is a rare phenomenon in which a secondary tumor colonizes within a primary tumor of a different histogenesis. It is hypothesized that TTM is encouraged by conditions that promote increased cell growth and division in the primary tumor, such as hypervascularity and expression of oncogenic cytokines. However, the exact causes of TTM likely vary on a case-by-case basis and are dependent on the microenvironment of both the primary and secondary tumors. Herein, we present the first reported example of TTM in which a pulmonary neuroendocrine tumor (NET) metastasizes to a renal oncocytoma. More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.9, pp. 2597-2597, 2025, DOI:10.32604/or.2025.071883 - 28 August 2025

Abstract This article has no abstract. More >