ADRIANA L. FERREIRA, GUSTAVO C. PARIS, ALINE DE A. AZEVEDO, ERIKA A. C. CORTEZ, SIMONE N. CARVALHO, LAIS DE CARVALHO, ALESSANDRA A. THOLE*
BIOCELL, Vol.46, No.8, pp. 1807-1813, 2022, DOI:10.32604/biocell.2022.019363
Abstract Mesenchymal stem cells (MSC) have pushed the field of stem cell-based therapies by inducing tissue
regeneration, immunosuppression, and angiogenesis mainly through vesicles and soluble factors release (paracrine
signaling). MSC-extracellular vesicles (MSC-EV) adaptable secretome and homing to injured sites allowed researchers
to unlock a new era of cell-free based therapy. In parallel, nanoparticles (NP) have been explored in contributing to
transport and drug delivery systems, giving drugs desired physical-chemical properties to exploit cell behavior.
However, NPs can be quickly recognized by immune cells and cleared from circulation. In this viewpoint, we explore
how combining both therapeutic… More >
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