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    ABSTRACT

    Mechano Growth Factor (MGF) Expression and Response to Multiple-Mechanical Stimulation after Biodegradable Stent Implantation

    Shuang Ge1, Ruolin Du1, Yuhua Huang1, Guixue Wang1, Yazhou Wang1, Tieying Yin1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 136-137, 2019, DOI:10.32604/mcb.2019.07317

    Abstract Stent implantation is the most effective method in the treatment of cardiovascular disease which always destroy the integrity of the vascular endothelium and the local mechanical environment at the stent segment was changed, especially the biodegradable stents [1]. In this study, 3D printed biodegradable poly (L-lactic acid) stents were implanted into SD rat abdominal aorta and the endothelialization, intimal hyperplasia, and MGF after stent implantation were studied. Besides, based on the MGF we explored the effects of mechanical stimulation on MGF express in vascular endothelial cells and smooth muscle cells, and also the effects of… More >

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