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  • Open Access

    ABSTRACT

    Dependency of Nuclear Deformation of Smooth Muscle Cells on Tissue Stretch Direction May Explain Anisotropic Response of Aortic Wall to Hypertension

    Takeo Matsumoto1,*, Chizuru Hirooka1, Yong Fan1, Junfeng Wang1, Naoki Mori1, Eijiro Maeda1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 81-81, 2019, DOI:10.32604/mcb.2019.07102

    Abstract Aortic wall thickens in response to hypertension. Many studies reported that the wall thickening occurs to maintain the wall stress in the circumferential direction at a constant level. In case of the longitudinal direction, however, there are few studies suggesting the constancy of the stress. Such anisotropic response may be attributable to the circumferential alignment of the smooth muscle cells (SMCs) in the wall [1]. However, to the authors’ knowledge, there are no study discussing the underlying mechanism of the anisotropic response. It has been reported that mechanical deformation of the nuclei causes transcription upregulation… More >

  • Open Access

    ARTICLE

    Structure - Function Relationships in the Stem Cell's Mechanical World B: Emergent Anisotropy of the Cytoskeleton Correlates to Volume and Shape Changing Stress Exposure

    Hana Chang*, Melissa L. Knothe Tate∗,†,‡

    Molecular & Cellular Biomechanics, Vol.8, No.4, pp. 297-318, 2011, DOI:10.3970/mcb.2011.008.297

    Abstract In the preceding study (Part A), we showed that prescribed seeding conditions as well as seeding density can be used to subject multipotent stem cells (MSCs) to volume changing stresses and that changes in volume of the cell are associated with changes in shape, but not volume, of the cell nucleus. In the current study, we aim to control the mechanical milieu of live cells using these prescribed seeding conditions concomitant to delivery of shape changing stresses via fluid flow, while observing adaptation of the cytoskeleton, a major cellular transducer that modulates cell shape, stiffness… More >

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