Nan Qin*1, Gui-Feng Tong†1, Li-Wei Sun‡, Xiao-Lin Xu†
Oncology Research, Vol.25, No.9, pp. 1471-1478, 2017, DOI:10.3727/096504017X14886689179993
Abstract Glioma, with varying malignancy grades and histological subtypes, is the most common primary brain tumor
in adults. Long noncoding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play
an important role in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA maternally
expressed gene 3 (MEG3) and microRNA-19a (miR-19a) in human glioma U87 and U251 cell lines. Real-time
PCR revealed that MEG3 was downregulated and miR-19a was upregulated in malignant glioma tissues and
cell lines. Bioinformatics analyses (TargetScan, miRanda, and starBase V2.0) showed that phosphatase and
tensin homolog (PTEN) is a… More >