LIANGYING ZHANG1, SHAOTING ZHANG1, ZHAOYANG FAN1, ZONGYING JIANG1,2, ANBU LIU1, SHUJING LI1,2, JIANMIN SUN1,*
BIOCELL, Vol.46, No.9, pp. 2081-2087, 2022, DOI:10.32604/biocell.2022.020109
- 18 May 2022
Abstract PI3 kinases are important for KIT signaling and KIT mutants mediated cell transformation. In order to know the
difference of PI3 kinase isoforms p110α and p110δ in the signaling of wild-type KIT and the often occurred KIT mutation
D816V in hematopoietic malignancy mastocytosis, the predominant PI3 kinase isoform p110δ in hematopoietic tissues was
knocked out in hematopoietic cells. We found that loss of p110δ expression dramatically inhibits PI3 kinase activation
mediated by both wild-type KIT and KIT/D816V. By over expression of p110α in p110δ knock out cells, wild-type KIT
mediated PI3 kinase activation was not More >
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