Hui Li*1, Han-Han Li†1, Qian Chen‡1, Yu-Yang Wang‡, Chang-Chang Fan‡, Yuan-Yuan Duan‡,
You Huang‡, Hui-Min Zhang‡, Jia-Peng Li‡, Xiao-Yu Zhang‡, Yuan Xiang‡, Chao-Jiang Gu‡, Li Wang§, Xing-Hua Liao‡, Tong-Cun Zhang‡¶
Oncology Research, Vol.28, No.9, pp. 885-897, 2020, DOI:10.3727/096504021X16274672547967
Abstract Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the
reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p)
is a low-expressed miRNA in breast cancer. The role of MKL-1’s regulation of DNMT1 in breast cancer cell
proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the
conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription
of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been
proved that DNMT1 is the… More >
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