Ziying Huang¹, Ruikang Ma¹, Anning Li², Yufei Cheng¹, Xiaolin Lin², Mengzhi Li³, Yu Zhang², Liping Shi¹, Linlin Dong^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.074419 - 30 January 2026

Abstract Epimedium is commonly used to treat bone injury and kidney disease, with prenylated flavonol glycosides (PFGs) as its active ingredients. It has attracted much attention due to prominent healthcare and therapeutic effects, but faces problems of adulteration with closely related species and confusion about geographical origins. In this study, multiple technical approaches were employed to identify its genetic characteristics and metabolic differences. Based on DNA barcoding, 20 batches of samples were analyzed. The genetic distances of matK, ITS and psbA-trnH within species were all smaller than those between species, and psbA-trnH along with ITS + psbA-trnH proved most effective… More >

Yun-Im Kang¹, Youn Jung Choi¹, Su Young Lee¹, Young-Ran Lee¹, Ki-Byung Lim^2,3, Yun-Jae Ahn^2,3,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.073138 - 30 January 2026

Abstract Cucumber mosaic virus (CMV) threatens lily production by reducing floral quality and enabling carry-over via infected planting stock. To explore tissue-specific host responses, we analyzed a legacy, single-replicate RNA-seq dataset from two cultivars, ‘Cancun’ and ‘Connecticut King’ (CK), profiling leaf (source) and bulb (sink) tissues at 0 and 28 days post-inoculation (dpi), alongside leaf DAS-ELISA. Principal component analysis indicated that tissue identity dominated the transcriptome (PC1 = 47.7%), with CMV treatment driving within-tissue shifts over time. Exploratory Gene Ontology/KEGG summaries and a focused marker panel revealed a consistent split: in leaves, genes linked to jasmonate/WRKY-associated… More >

Hyung Seok Kim^1,#, Ju A Son^2,#, Minji Kang^3,4,#, Soon Sun Kim³, Geum Ok Baek³, Moon Gyeong Yoon³, Se Ha Jang^3,4, Dokyung Jung⁵, Ji Eun Han³, Jae Youn Cheong^3,*, Jung Woo Eun^3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070392 - 19 January 2026

Abstract Objectives: Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 (EV-GULP1) as a novel, noninvasive biomarker for HCC detection and prognosis, leveraging the potential of tumor-specific molecules carried by small extracellular vesicles (EVs). Methods: The study utilized both internal and external cohorts of HCC patients and controls. Small EVs were isolated from serum samples, then characterized and validated to confirm their identity. The expression levels of EV-GULP1 were quantified using quantitative reverse transcription… More >

Bu Zou^1,#, Yi-En Xu^2,#, Hui-Chan He³, Zu-Lu Ye², Da-Lei Zhou², Cai-Yun He^2,*, Chan Huang^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069453 - 19 January 2026

Abstract Objectives: Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment. Methods: PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters… More >

Se Ha Jang^1,2,#, Hyung Seok Kim^3,#, Jung Woo Eun^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

Wen-Shou Tan^1,#, Hsuan Kuo^2,#, Chang-Ge Jiang¹, Mei-Han Lu¹, Yi-He Lu¹, Yung-Li Wang¹, Ching-Shuen Wang¹, Thi Thuy Tien Vo³, I-Ta Lee^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070871 - 30 December 2025

Abstract This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection More >

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Xu Guo¹, Yanan Yu², Xiaolin Ma³, Yuanjie Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069274 - 30 December 2025

Abstract Background: Long non-coding RNAs (lncRNAs) act as epigenetic regulators for tumor hallmarks. This investigation sought to probe the carcinogenic trait of PAN3-AS1 across pan-cancer comprehensively. Methods: We studied the diagnostic and prognostic features and the immune landscape of PAN3-AS1 across pan-cancer by bioinformatics approaches. The hierarchical regulatory networks governing PAN3-AS1 expression in colon cancer were explored via chromatin immunoprecipitation, luciferase activity assays, and RNA immunoprecipitation, etc. We screened drugs sensitive to WAP four-disulfide core domain 13 (WFDC13) by virtual screening and molecular docking. Results: Single-cell transcriptomics demonstrated that a variety of immune populations abnormally expressed PAN3-AS1… More >

Ashok Kumar Sah^1,*, Ranjay Kumar Choudhary^1,2, Velilyaeva Alie Sabrievna³, Karomatov Inomdzhon Dzhuraevich⁴, Anass M. Abbas⁵, Manar G. Shalabi⁵, Nadeem Ahmad Siddique⁶, Raji Rubayyi Alshammari⁷, Navjyot Trivedi⁸, Rabab H. Elshaikh¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

Shaoyan Wu^1,2, Jie Tian^1,2, Yiyan Wang^1,2, Muhammad Arif^1,2, Shuyao Wang^1,2, Jing Wang^1,2, Zhuoyao Yang^1,2, Ruhong Xu^1,2,*, Luhua Li^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 3913-3924, 2025, DOI:10.32604/phyton.2025.072229 - 29 December 2025

Abstract Wheat grain morphology, particularly grain length (GL) and width (GW), is a key determinant of yield. To improve the suboptimal grain dimensions of the local anthocyanin-rich variety Guizi 1 (GZ1), we crossed it with Zhongyan 96-3 (ZY96-3), an elite germplasm known for faster grain filling and superior grain size. A genotyping-by-sequencing (GBS) approach was applied to an F₂ population of 110 individuals derived from GZ1 × ZY96-3, resulting in the identification of 23,134 high-quality SNPs. Most of the SNPs associated with GL and GW were clustered on chromosomes 2B, 3A, and 3B. QTL mapping for GL… More >