Jianli Chen*1, Xiaowen Chen†1
Oncology Research, Vol.26, No.6, pp. 913-922, 2018, DOI:10.3727/096504017X15135941182107
Abstract Breast cancer remains a public health issue on a global scale. The present study aimed to explore the functional role of MYB proto-oncogene like 2 (MYBL2) in breast cancer, as well as underlying mechanisms.
The regulatory relationship between miR-143-3p and MYBL2 was analyzed, and the effects of dysregulation
of miR-143-3p and MYBL2 on cell proliferation and apoptosis were investigated. The results showed that
MYBL2 and miR-143-3p were inversely expressed in breast cancer tissues and cells: MYBL2 was highly
expressed, whereas miR-143-3p was lowly expressed. MYBL2 was confirmed as a target gene of miR-143-3p.
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