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  • Open Access

    ARTICLE

    Simulation of Offshore Wind Turbine Blade Docking Based on the Stewart Platform

    Yi Zhang*, Jiamin Guo, Huanghua Peng

    Energy Engineering, Vol.120, No.11, pp. 2489-2502, 2023, DOI:10.32604/ee.2023.029496

    Abstract The windy environment is the main cause affecting the efficiency of offshore wind turbine installation. In order to improve the stability and efficiency of single-blade installation of offshore wind turbines under high wind speed conditions, the Stewart platform is used as an auxiliary tool to help dock the wind turbine blade in this paper. In order to verify the effectiveness of the Stewart platform for blade docking, a blade docking simulation system consisting of the Stewart platform, wind turbine blade, and wind load calculation module was built based on Simulink/Simscape Multibody. At the same time, the PID algorithm is used… More >

  • Open Access

    ARTICLE

    A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs)

    WENQI CHEN1,#, XIAOYANG CHU2,#, YANG ZENG3,#, YOUSHENG YAN4, YIPENG WANG4, DONGLAN SUN1, DONGLIANG ZHANG5, JING ZHANG1,*, KAI YANG4,*

    BIOCELL, Vol.47, No.7, pp. 1561-1569, 2023, DOI:10.32604/biocell.2023.028851

    Abstract Background: Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has a vital role in osteogenesis. However, the mechanism underlying the regulation of ROR2 in osteogenic differentiation is still poorly comprehended. A previous study by our research group showed that a novel compound heterozygous ROR2 variation accounted for the autosomal recessive Robinow syndrome (ARRS). This study attempted to explore the impact of the ROR2: c.904C>T variant specifically on the osteogenic differentiation of BMSCs. Methods: Coimmunoprecipitation (CoIP)-western blotting was carried out to identify the interaction between ROR2 and Wnt5a. Double-immunofluorescence staining was used for determining the expressions and co-localization of ROR2 and Wnt5a… More > Graphic Abstract

    A novel mutation in <i>ROR2</i> led to the loss of function of <i>ROR2</i> and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells (BMSCs)

  • Open Access

    ARTICLE

    Static Bending Creep Properties of Glass Fiber Surface Composite Wood

    Shang Zhang1, Jie Wang2, Benjamin Rose5, Yushan Yang3, Qingfeng Ding1, Bengang Zhang4,*, Chunlei Dong2,*

    Journal of Renewable Materials, Vol.11, No.6, pp. 2881-2891, 2023, DOI:10.32604/jrm.2023.028160

    Abstract To study the static bending creep properties of glass fiber reinforced wood, glass fiber reinforced poplar (GFRP) specimens were obtained by pasting glass fiber on the upper and lower surfaces of Poplar (Populus euramevicana, P), the performance of Normal Creep (NC) and Mechanical Sorptive Creep (MSC) of GFRP and their influencing factors were tested and analyzed. The test results and analysis show that: (1) The MOE and MOR of Poplar were increased by 17.06% and 10.00% respectively by the glass fiber surface reinforced composite. (2) The surface reinforced P with glass fiber cloth only exhibits the NC pattern of wood… More >

  • Open Access

    ARTICLE

    Immunoregulatory effects of human amniotic mesenchymal stem cells and their exosomes on human peripheral blood mononuclear cells

    XIN TIAN, XIANGLING HE*, SHUQIN QIAN, RUNYING ZOU, KEKE CHEN, CHENGGUANG ZHU, ZEXI YIN

    BIOCELL, Vol.47, No.5, pp. 1085-1093, 2023, DOI:10.32604/biocell.2023.027090

    Abstract Background: The immunomodulatory effects of mesenchymal stem cells (MSCs) and their exosomes have been receiving increasing attention. This study investigated the immunoregulatory effects of human amniotic mesenchymal stem cells (hAMSCs) and their exosomes on phytohemagglutinin (PHA)-induced peripheral blood mononuclear cells (PBMCs). Methods: The hAMSCs used in the experiment were identified by light microscopy and flow cytometry, and the differentiation ability of the cells was determined by Oil Red O and Alizarin Red staining. The expressions of transforming growth factor (TGF)-β, indoleamine 2,3-dioxygenase (IDO), cyclooxygenase-2 (COX-2), hepatocyte growth factor (HGF), and interleukin (IL)-6 were detected by quantitative real-time polymerase chain reaction… More >

  • Open Access

    ARTICLE

    MSCNN-LSTM Model for Predicting Return Loss of the UHF Antenna in HF-UHF RFID Tag Antenna

    Zhao Yang1, Yuan Zhang1, Lei Zhu2,*, Lei Huang1, Fangyu Hu3, Yanping Du1, Xiaowei Li1

    CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 2889-2904, 2023, DOI:10.32604/cmc.2023.037297

    Abstract High-frequency (HF) and ultrahigh-frequency (UHF) dual-band radio frequency identification (RFID) tags with both near-field and far-field communication can meet different application scenarios. However, it is time-consuming to calculate the return loss of a UHF antenna in a dual-band tag antenna using electromagnetic (EM) simulators. To overcome this, the present work proposes a model of a multi-scale convolutional neural network stacked with long and short-term memory (MSCNN-LSTM) for predicting the return loss of UHF antennas instead of EM simulators. In the proposed MSCNN-LSTM, the MSCNN has three branches, which include three convolution layers with different kernel sizes and numbers. Therefore, MSCNN… More >

  • Open Access

    ARTICLE

    Experimental Research on the Millimeter-Scale Distribution of Oil in Heterogeneous Reservoirs

    Zhao Yu1,2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.6, pp. 1521-1534, 2023, DOI:10.32604/fdmp.2023.023296

    Abstract Oil saturation is a critical parameter when designing oil field development plans. This study focuses on the change of oil saturation during water flooding. Particularly, a meter-level artificial model is used to conduct relevant experiments on the basis of similarity principles and taking into account the layer geological characteristics of the reservoir. The displacement experiment’s total recovery rate is 41.35%. The changes in the remaining oil saturation at a millimeter-scale are examined using medical spiral computer tomography principles. In all experimental stages, regions exists where the oil saturation decline is more than 10.0%. The shrinkage percentage is 20.70% in the… More >

  • Open Access

    REVIEW

    Therapeutic application of mesenchymal stem cells-derived extracellular vesicles in colorectal cancer

    MOHADESEH NEMATI1, YOUSEF RASMI1, JAFAR REZAIE2,*

    BIOCELL, Vol.47, No.3, pp. 455-464, 2023, DOI:10.32604/biocell.2023.025603

    Abstract Colorectal cancer (CRC) is the third most common cancer and the leading cause of cancer death globally. Resistance to therapy is a challenge for CRC treatment. Mesenchymal stem cells (MSCs) have become one of the furthermost effective approaches for tumor treatment due to their specific feature; however, their therapeutic function is controversial. Recently, extracellular vesicles (EVs) derived from MSCs (MSCs-EVs) have attracted extensive research attention due to their promising role in CRC treatment. EVs are cell-derived vesicles that transfer different biomolecules between cells, contributing to intracellular communication. MSCs-EVs can suppress CRC by delivering therapeutic agents to tumor cells. Several studies… More >

  • Open Access

    ARTICLE

    The antioxidant trolox inhibits aging and enhances prostaglandin E-2 secretion in mesenchymal stem cells

    XIAOXU ZHANG1,2, LIN ZHANG1, LIN DU3, HUIYAN SUN4, XIA ZHAO2, YANG SUN1, WEI WANG2,*, LISHENG WANG1,3,*

    BIOCELL, Vol.47, No.2, pp. 385-392, 2023, DOI:10.32604/biocell.2023.025203

    Abstract Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. However, during in vitro expansion, MSCs are prone to aging, which largely limits their application. Prostaglandin E-2 (PGE-2) is a key effector secreted by MSCs to exert immunomodulatory effects. By screening the compound library for PGE-2 secretion, the antioxidant trolox was verified as a stimulator of MSCs to secrete PGE-2. The effect of antioxidant trolox on biological characteristics of MSCS, including aging, proliferation, and gene expression, was examined. The results demonstrated that trolox can resist aging,… More >

  • Open Access

    VIEWPOINT

    Production of mesenchymal stem cell derived-secretome as cell-free regenerative therapy and immunomodulation: A biomanufacturing perspective

    FUAD GANDHI TORIZAL1,2,*, FRANSISCUS FIANO ANTHONY KERANS3, ANNISA KHUMAIRA1

    BIOCELL, Vol.46, No.8, pp. 1885-1891, 2022, DOI:10.32604/biocell.2022.019591

    Abstract The potential of mesenchymal stem cells (MSCs) in regenerative medicine has been largely known due to their capability to induce tissue regeneration in vivo with minimum inflammation during implantation. This adult stem cell type exhibit unique features of tissue repair mechanism and immune modulation mediated by their secreted factors, called secretome. Recently, the utilization of secretome as a therapeutic agent provided new insight into cell-free therapy. Nevertheless, a sufficient amount of secretome is necessary to realize their applications for translational medicine which required a proper biomanufacturing process. Several factors related to their production need to be considered to produce a… More >

  • Open Access

    ARTICLE

    Long non-coding RNA MIR22HG inhibits the adipogenesis of human bone marrow mesenchymal stem cells with the involvement of Wnt/β-catenin pathway

    CHANYUAN JIN1,4,#, ZIYAO ZHUANG2,4,#, LINGFEI JIA3,4,*, YUNFEI ZHENG2,4,*

    BIOCELL, Vol.46, No.7, pp. 1717-1724, 2022, DOI:10.32604/biocell.2022.018706

    Abstract Osteoporosis is a frequently occurring bone remodeling disorder worldwide with one characteristic being decreasing bone mineral density and a predisposition to bone fracture, which diminishes patients’ quality of life. Several studies showed that imbalance between the osteogenesis and adipogenesis of bone marrow mesenchymal stem cells (BMSCs) took part in the development of osteoporosis. In previous study, we found MIR22HG regulated the osteogenesis of human BMSCs positively. In this study, we found that MIR22HG was decreased during the adipogenesis of human BMSCs and exerted negative effects on adipogenesis with the involvement of Wnt/β-catenin signaling pathway both in vitro and in vivo.… More >

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