Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1385-1385, 2024, DOI:10.32604/or.2024.055037

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1379-1379, 2024, DOI:10.32604/or.2024.055034

Abstract This article has no abstract. More >

RUIFANG LI¹, XINRONG NAN^2,*, MING LI^3,*, OMAR RAHHAL³

Oncology Research, Vol.32, No.8, pp. 1323-1334, 2024, DOI:10.32604/or.2024.046965

Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays… More >

MING ZHUANG, XUE ZHANG, LU LI, LIMING WEN, JIAMIN QIN^*

Oncology Research, Vol.32, No.8, pp. 1347-1357, 2024, DOI:10.32604/or.2024.046170

Abstract Hepatocellular carcinoma (HCC) poses a significant threat to human health. Resistance to sorafenib in the chemotherapy of HCC is a common and significant issue that profoundly impacts clinical treatment. While several members of the transmembrane (TMEM) protein family have been implicated in the occurrence and progression of HCC, the association between TMEM39b and HCC remains unexplored. This study revealed a significant overexpression of TMEM39b in HCC, which correlated with a poor prognosis. Subsequent investigation revealed that RAS-selective lethal 3 (RSL3) induced pronounced ferroptosis in HCC, and knocking down the expression of TMEM39b significantly decreased its More >

WEI JIANG¹, MEI ZHOU^2,*

Oncology Research, Vol.32, No.8, pp. 1359-1368, 2024, DOI:10.32604/or.2024.043423

Abstract Multiple myeloma (MM) is a plasma cell malignancy and remains incurable as it lacks effective curative approaches; thus, novel therapeutic strategies are desperately needed. The study aimed to explore the therapeutic role of dihydromyricetin (DHM) in MM and explore its mechanisms. Human MM and normal plasma samples, human MM cell lines, and normal plasma cells were used for in vitro experiments. Cell counting kit-8 (CCK-8), flow cytometry, and trans-well assays were performed for the assessment of cell viability, apoptosis, migration, and invasion, respectively. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess the mRNA expression… More > Graphic Abstract

Md. Atiqur Rahman¹, Mustavi Ibne Masum¹, Khan Md Hasib², M. F. Mridha^3,*, Sultan Alfarhood⁴, Mejdl Safran^4,*, Dunren Che⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2425-2448, 2024, DOI:10.32604/cmes.2024.050760

Abstract Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global mortality. This study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging (MRI). It focuses on distinguishing between Low-Grade Gliomas (LGG) and High-Grade Gliomas (HGG). LGGs are benign and typically manageable with surgical resection, while HGGs are malignant and more aggressive. The research introduces an innovative custom convolutional neural network (CNN) model, Glioma-CNN. GliomaCNN stands out as a lightweight CNN model compared to its predecessors. The research utilized the BraTS 2020 More >

Ziqiao Zhou¹, Tianyang Zhou^1,*, Jinghao Xu², Junhu Zhu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2613-2634, 2024, DOI:10.32604/cmes.2023.028553

Abstract Intelligent penetration testing is of great significance for the improvement of the security of information systems, and the critical issue is the planning of penetration test paths. In view of the difficulty for attackers to obtain complete network information in realistic network scenarios, Reinforcement Learning (RL) is a promising solution to discover the optimal penetration path under incomplete information about the target network. Existing RL-based methods are challenged by the sizeable discrete action space, which leads to difficulties in the convergence. Moreover, most methods still rely on experts’ knowledge. To address these issues, this paper… More >

RUOYU CHEN¹, YIMAN WU¹, FENG WANG¹, JUNTAO ZHOU¹, HUAZHANG ZHUANG¹, WEI LI^2,*

BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074

Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

Binyang Zhao¹, Fengchan Wu², Guojun Cai³, Peiyu Xi², Yulin Guo², Anding Li^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1345-1363, 2024, DOI:10.32604/phyton.2024.050950

Abstract In order to explore the response mechanism of Passiflora edulis Sims to drought stress, the changes in morphological and physiological traits of Passiflora edulis Sims under different drought conditions were studied. A total of 7 germplasm resources of Passiflora edulis Sims were selected and tested under drought stress by the pot culture method under 4 treatment levels: 75%–80% (Control, CK) of maximum field water capacity, 55%–60% (Light Drought, LD) of maximum field water capacity, i.e., mild drought, 40%–45% (Moderate Drought, MD) of maximum field water capacity, i.e., moderate drought and 30%–35% (Severe Drought, SD) of maximum field water… More >

Xiao Huang^1,2, Jin Yang^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1393-1406, 2024, DOI:10.32604/fdmp.2024.046360

Abstract Cement-based materials are fundamental in the construction industry, and enhancing their properties is an ongoing challenge. The use of superabsorbent polymers (SAP) has gained significant attention as a possible way to improve the performance of cement-based materials due to their unique water-absorption and retention properties. This study investigates the multifaceted impact of kaolin intercalation-modified superabsorbent polymers (K-SAP) on the properties of cement mortar. The results show that K-SAP significantly affects the cement mortar’s rheological behavior, with distinct phases of water absorption and release, leading to changes in workability over time. Furthermore, K-SAP alters the hydration More >