Rabindranath Bera^1,#, Yotaro Ochi^2,3, Ying-Jung Huang¹, Ming-Chung Kuo^1,4, Kenichi Yoshida⁵, Seishi Ogawa², Lee-Yung Shih^1,4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070259 - 30 December 2025

Abstract Background: Breakpoint Cluster Region-Abelson (BCR::ABL1) fusion protein is essential in the pathogenesis of chronic myeloid leukemia (CML); however, the chronic-to-blast phase transformation remains elusive. We identified novel kinesin light chain 2 (KLC2) mutations in CML-myeloid blast phase patients. We aimed to examine the functional role of KLC2 mutations in leukemogenesis. Methods: To evaluate the biological role of KLC2 mutants (MT) in CML cells, we expressed KLC2-MT in different human CML cell lines harboring BCR::ABL1 and performed immunoblot, immunofluorescence, cell proliferation, differentiation, and apoptosis; Tyrosine kinase inhibitor (TKI)-drug activities; and clonogenic assays for in vitro functional analyses. We co-expressed KLC2-MT… More >

K. Naga Venkata Siva¹, Damodhar Reddy², P. Krishna Murthy³, Kiran Kumar Pulamolu⁴, M. Dharani⁵, T. Venkatakrishnamoorthy^6,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.072982 - 27 December 2025

Abstract Conventional multilevel inverters often suffer from high harmonic distortion and increased design complexity due to the need for numerous power semiconductor components, particularly at elevated voltage levels. Addressing these shortcomings, this work presents a robust 15-level Packed U Cell (PUC) inverter topology designed for renewable energy and grid-connected applications. The proposed system integrates a sensor less proportional-resonant (PR) controller with an advanced carrier-based pulse width modulation scheme. This approach efficiently balances capacitor voltage, minimizes steady-state error, and strongly suppresses both zero and third-order harmonics resulting in reduced total harmonic distortion and enhanced voltage regulation. Additionally, More >

Meenakshi Aggarwal¹, Vikas Khullar^2,*, Nitin Goyal³

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-31, 2026, DOI:10.32604/cmc.2025.072673 - 09 December 2025

Abstract The Internet of Vehicles, or IoV, is expected to lessen pollution, ease traffic, and increase road safety. IoV entities’ interconnectedness, however, raises the possibility of cyberattacks, which can have detrimental effects. IoV systems typically send massive volumes of raw data to central servers, which may raise privacy issues. Additionally, model training on IoV devices with limited resources normally leads to slower training times and reduced service quality. We discuss a privacy-preserving Federated Split Learning with Tiny Machine Learning (TinyML) approach, which operates on IoV edge devices without sharing sensitive raw data. Specifically, we focus on… More >

Qianqian Hu, Chuhan Li, Mohan Zhang, Fang Liu^*

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-17, 2026, DOI:10.32604/cmc.2025.068225 - 10 November 2025

Abstract Due to the digital transformation tendency among cultural institutions and the substantial influence of the social media platform, the demands of visual communication keep increasing for promoting traditional cultural artifacts online. As an effective medium, posters serve to attract public attention and facilitate broader engagement with cultural artifacts. However, existing poster generation methods mainly rely on fixed templates and manual design, which limits their scalability and adaptability to the diverse visual and semantic features of the artifacts. Therefore, we propose CAPGen, an automated aesthetic Cultural Artifacts Poster Generation framework built on a Multimodal Large Language More >

Nader Karmous¹, Wadii Jlassi¹, Mohamed Ould-Elhassen Aoueileyine¹, Imen Filali^2,*, Ridha Bouallegue¹

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4363-4393, 2025, DOI:10.32604/cmes.2025.074178 - 23 December 2025

Abstract This paper introduces a robust Distributed Denial-of-Service attack detection framework tailored for Software-Defined Networking based Internet of Things environments, built upon a novel, synthetic multi-vector dataset generated in a Mininet-Ryu testbed using real-time flow-based labeling. The proposed model is based on the XGBoost algorithm, optimized with Principal Component Analysis for dimensionality reduction, utilizing lightweight flow-level features extracted from OpenFlow statistics to classify attacks across critical IoT protocols including TCP, UDP, HTTP, MQTT, and CoAP. The model employs lightweight flow-level features extracted from OpenFlow statistics to ensure low computational overhead and fast processing. Performance was rigorously… More >

Miah A. Robinson, Abdulghani M. Abdulghani, Mokhles M. Abdulghani, Khalid H. Abed^*

Journal on Artificial Intelligence, Vol.7, pp. 615-632, 2025, DOI:10.32604/jai.2025.073535 - 01 December 2025

Abstract Ensuring the safety of Artificial Intelligence (AI) is essential for providing dependable services, especially in various sectors such as the military, education, healthcare, and automotive industries. A highly effective method to boost the precision and performance of an AI agent involves multi-configuration training, followed by thorough evaluation in a specific setting to gauge performance outcomes. This research thoroughly investigates the design of three AI agents, each configured with a different number of hidden units. The first agent is equipped with 128 hidden units, the second with 256, and the third with 512, all utilizing the… More >

Zhenzhen Shen^1,2, Kang Yang², Dengfeng Wei², Quansheng Liang², Zhenpeng Ma², Hong Wang², Keyu Wang², Chunwei Zhang², Xiaohu Yang^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2741-2760, 2025, DOI:10.32604/fdmp.2025.070395 - 01 December 2025

Abstract The rapid prediction of seepage mass flow in soil is essential for understanding fluid transport in porous media. This study proposes a new method for fast prediction of soil seepage mass flow by combining mesoscopic modeling with deep learning. Porous media structures were generated using the Quartet Structure Generation Set (QSGS) method, and a mesoscopic-scale seepage calculation model was applied to compute flow rates. These results were then used to train a deep learning model for rapid prediction. The analysis shows that larger average pore diameters lead to higher internal flow velocities and mass flow More >

Kinzah Noor¹, Agbotiname Lucky Imoize^2,*, Michael Adedosu Adelabu³, Cheng-Chi Lee^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 1575-1664, 2025, DOI:10.32604/cmes.2025.073200 - 26 November 2025

Abstract The envisioned 6G wireless networks demand advanced Multiple Access (MA) schemes capable of supporting ultra-low latency, massive connectivity, high spectral efficiency, and energy efficiency (EE), especially as the current 5G networks have not achieved the promised 5G goals, including the projected 2000 times EE improvement over the legacy 4G Long Term Evolution (LTE) networks. This paper provides a comprehensive survey of Artificial Intelligence (AI)-enabled MA techniques, emphasizing their roles in Spectrum Sensing (SS), Dynamic Resource Allocation (DRA), user scheduling, interference mitigation, and protocol adaptation. In particular, we systematically analyze the progression of traditional and modern… More > Graphic Abstract

Suhyeon Lee¹, Hwankuk Kim^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.2, pp. 2657-2682, 2025, DOI:10.32604/cmes.2025.070627 - 26 November 2025

Abstract The open nature and heterogeneous architecture of Open Radio Access Network (Open RAN) undermine the consistency of security policies and broaden the attack surface, thereby increasing the risk of security vulnerabilities. The dynamic nature of network performance and traffic patterns in Open RAN necessitates advanced detection models that can overcome the constraints of traditional techniques and adapt to evolving behaviors. This study presents a methodology for effectively detecting malicious traffic in Open RAN by utilizing an Artificial-Intelligence/Machine-Learning (AI/ML) Framework. A hybrid Transformer–Convolutional-Neural-Network (Transformer-CNN) ensemble model is employed for anomaly detection. The proposed model generates final More >

Sara Y. Aldeghaither, Jawaher Alsughayyir, Sabiha Fatima, Mohammad A. Alfhili^*

BIOCELL, Vol.49, No.11, pp. 2167-2180, 2025, DOI:10.32604/biocell.2025.071827 - 24 November 2025

Abstract Objectives: Targeting epigenetic modifications in anticancer therapy is a promising approach to overcoming cancer cell chemoresistance. The histone deacetylase/DNA methyltransferase inhibitor, parthenolide (PTL), has antitumor activity, but contrasting findings exist on its effect in normal cells. This study aims to examine the non-genomic toxic mechanisms of PTL in human erythrocytes. Methods: Cell death as stimulated by 20–200 μM of PTL for 24 h at 37°C was assessed using fluorescence-assorted cell sorting and spectrophotometric assays. Canonical markers of cell death, including membrane scrambling, oxidative stress, and Ca²⁺ mobilization, were captured by annexin V-fluorescein isothiocyanate, 2^′,7^′-dichlorodihydrofluorescein diacetate, and… More >