KAITIAN ZHANG1,#, MINGZHU LI2,#,*, JIANPING ZHANG3, JINFENG LI2, KUNLANG LI2, HUANQIAN LU2, JINYAN LV2
BIOCELL, Vol.48, No.10, pp. 1489-1501, 2024, DOI:10.32604/biocell.2024.053930
- 02 October 2024
Abstract Objective: Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion (MI/R) can confer cardioprotective benefits. This study investigates whether Lovastatin can modulate the Yes-associated protein/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ) signaling pathway to mitigate cardiomyocyte injury caused by hypoxia/reoxygenation (H/R). Methods: The in vitro MI/R model was established by H/R in rat myocardial H9c2 cells, and the cells were pretreated with varying doses of Lovastatin before reoxygenation. The extent of cellular injury was evaluated by measuring the myocardial enzyme content and cell viability. The levels of oxidative stress and inflammatory factors were quantified by enzyme-linked… More >
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