Angela Silvano*†1, Giulio Menegazzi*1, Silvia Peppicelli*1,
Caterina Mancini*, Alessio Biagioni*, Alessandro Tubita*, Ignazia Tusa*, Jessica Ruzzolini*, Matteo Lulli*, Elisabetta Rovida*, Persio Dello Sbarba*
Oncology Research, Vol.29, No.1, pp. 33-46, 2021, DOI:10.3727/096504022X16442289212164
Abstract This study was directed to deepen the effects of nutrient shortage on BCR/Ablprotein expression and signaling in
chronic myeloid leukemia (CML) cells. The backbone of the study was cell culture in medium lacking glucose,
the consumption of which we had previously shown to drive BCR/Ablprotein suppression, and glutamine, the
other main nutrient besides glucose. In this context, we focused on the role of lactate, the main by-product of
glucose metabolism under conditions of rapid cell growth, in particular as a modulator of the maintenance of
CML stem/progenitor cell potential, a crucial determinant of disease course and relapse of disease. The… More >
Login
Register
