Hongde Li*†‡, Yueshuo Li*†‡, Jianmin Hu*†‡, Sufang Liu§, Xiangjian Luo*†‡¶, Min Tang*†‡,
Ann M. Bode#, Zigang Dong#**, Xinqi Liu††, Weihua Liao‡‡, Ya Cao*†‡¶ §§¶¶
Oncology Research, Vol.28, No.7-8, pp. 763-778, 2020, DOI:10.3727/096504021X16135618512563
Abstract Epstein–Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) plays an important oncogenic role in
the viral latent infection. Recently, increasing evidence indicates that the high expression of LMP1 during EBV
lytic cycle is related to the viral lytic replication. However, the mechanism by which LMP1 regulates EBV
lytic replication remains unclear. (−)-Epigallocatechin-3-gallate (EGCG) prevents carcinogenesis by directly
targeting numerous membrane proteins and effectively inhibits EBV lytic cascade. Here, we demonstrated that
LMP1 promotes EBV lytic replication through the downstream signal molecules MAPKs, including ERKs,
p38, and JNKs. LMP1 induces the phosphorylation of p53 through MAPKs to enhance the ability of… More >
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