ARCHITTAPON NOKKEAW1,2,3,#, PANNATHON THAMJAMRASSRI1,2,3,#, NAPHAT CHANTARAVISOOT1,4, PISIT TANGKIJVANICH1,2,*, CHAIYABOOT ARIYACHET1,2,*
Oncology Research, Vol.31, No.6, pp. 989-1005, 2023, DOI:10.32604/or.2023.030395
- 15 September 2023
Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer death worldwide; nevertheless, current therapeutic options are limited or ineffective for many patients. Therefore, elucidation of molecular mechanisms in HCC biology could yield important insights for the intervention of novel therapies. Recently, various studies have reported dysregulation of long non-coding RNAs (lncRNAs) in the initiation and progression of HCC, including H19; however, the biological function of H19 in HCC remains unclear. Here, we show that knockdown of H19 disrupted HCC cell growth, impaired the G1-to-S phase transition, and promoted apoptosis, while overexpression of H19 yielded the… More >
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