Xingquan Zhai, Wei Xu
Oncology Research, Vol.26, No.7, pp. 1063-1072, 2018, DOI:10.3727/096504018X15152072098476
Abstract This study aimed to explore the biological functions of long noncoding RNA activated by transforming growth
factor-b (lncRNA-ATB) in bladder cancer cells. For the expressions of lncRNA-ATB, miR-126, and KRAS,
T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then cell viability, migration,
invasion, and apoptosis as well as the protein levels of apoptosis-related factors and PI3K/AKT and mTOR
signal pathways were measured. The relationships of lncRNA-ATB and miR-126 or miR-126 and KRAS were
analyzed by Dual-Luciferase Reporter assay. Functional experiments showed that lncRNA-ATB overexpression significantly promoted cell viability, migration, and invasion in T24 More >
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