Geqiong Xiao*, Qiong Wang*, Bo Li†, Xiaohui Wu‡, Hui Liao*, Yili Ren*, Ning Ai†*
Oncology Research, Vol.26, No.8, pp. 1183-1189, 2018, DOI:10.3727/096504018X15151495109394
Abstract Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p
(miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown.
In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover,
miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably
enhanced the growth suppression More >
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