Fan-Chun Meng, Jun-Kai Lin
Oncology Research, Vol.27, No.2, pp. 139-146, 2019, DOI:10.3727/096504018X15185747911701
Abstract Inhibition of tumor metastasis is one of the most important purposes in colorectal cancer (CRC) treatment. This
study aimed to explore the effects of liquiritigenin, a flavonoid extracted from the roots of Glycyrrhiza uralensis Fisch, on HCT116 cell proliferation, invasion, and epithelial-to-mesenchymal transition (EMT). We found
that liquiritigenin significantly inhibited HCT116 cell proliferation, invasion, and the EMT process, but had no
influence on cell apoptosis. Moreover, liquiritigenin remarkably reduced the expression of runt-related transcription factor 2 (Runx2) in HCT116 cells. Overexpression of Runx2 obviously reversed the liquiritigenininduced invasion and EMT inhibition. Furthermore, liquiritigenin inactivated the phosphoinositide 3-kinase/
protein kinase B… More >
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